Control of immune pathology by regulatory T cells

被引：246
作者：
Mason, D
Powrie, F
机构：
[1] Univ Oxford, Sir William Dunn Sch Pathol, MRC, Cellular Immunol Unit, Oxford OX1 3RE, England
[2] Univ Oxford, John Radcliffe Hosp, Nuffield Dept Surg, Oxford OX3 9DU, England
来源：
CURRENT OPINION IN IMMUNOLOGY | 1998年 / 10卷 / 06期
基金：
英国惠康基金;
关键词：
D O I：
10.1016/S0952-7915(98)80084-8
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
There is now compelling evidence that immune responses for both foreign and self antigens are downregulated by T cells that are specialised for this function; these are known as regulatory T (T reg) cells. This review describes progress in the characterisation of the T reg cells that mediate both mucosal tolerance and tolerance to self antigens. The recent work on the antigen specificity, generation and mode of action of T reg cells is also reviewed.
引用
收藏
页码：649 / 655
页数：7
相关论文
共 71 条
[1]   Islet T cells secreting IFN-γ in NOD mouse diabetes:: Arrest by p277 peptide treatment [J].
Ablamunits, V ;
Elias, D ;
Reshef, T ;
Cohen, IR .
JOURNAL OF AUTOIMMUNITY, 1998, 11 (01) :73-81
[2]   Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation [J].
Asano, M ;
Toda, M ;
Sakaguchi, N ;
Sakaguchi, S .
JOURNAL OF EXPERIMENTAL MEDICINE, 1996, 184 (02) :387-396
[3]  
Barone KS, 1998, J IMMUNOL, V161, P154
[4]  
Bemelman F, 1998, J IMMUNOL, V160, P2645
[5]   Transforming growth factor beta (TGF-beta)-dependent inhibition of T helper cell 2 (Th2)-induced autoimmunity by self-major histocompatibility complex (MHC) class II-specific, regulatory CD4(+) T cell lines [J].
Bridoux, F ;
Badou, A ;
Saoudi, A ;
Bernard, I ;
Druet, E ;
Pasquier, R ;
Druet, P ;
Pelletier, L .
JOURNAL OF EXPERIMENTAL MEDICINE, 1997, 185 (10) :1769-1775
[6]   Interleukin 10 secretion and impaired effector function of major histocompatibility complex class II-restricted T cells anergized in vivo [J].
Buer, J ;
Lanoue, A ;
Franzke, A ;
Garcia, C ;
von Boehmer, H ;
Sarukhan, A .
JOURNAL OF EXPERIMENTAL MEDICINE, 1998, 187 (02) :177-183
[7]  
Cameron MJ, 1997, J IMMUNOL, V159, P4686
[8]   REGULATORY T-CELL CLONES INDUCED BY ORAL TOLERANCE - SUPPRESSION OF AUTOIMMUNE ENCEPHALOMYELITIS [J].
CHEN, YH ;
KUCHROO, VK ;
INOBE, J ;
HAFLER, DA ;
WEINER, HL .
SCIENCE, 1994, 265 (5176) :1237-1240
[9]   Infectious tolerance [J].
Cobbold, S ;
Waldmann, H .
CURRENT OPINION IN IMMUNOLOGY, 1998, 10 (05) :518-524
[10]  
Duchmann R, 1995, CLIN EXP IMMUNOL, V102, P448
12345678