Understanding the interplay between host immunity and Epstein-Barr virus in NPC patients

被引：44
作者：
Shen, Yong [1 ,2 ]
Zhang, Suzhan [1 ,2 ]
Sun, Ren [1 ,2 ,3 ]
Wu, Tingting [1 ,2 ,3 ]
Qian, Jing [2 ,4 ]
机构：
[1] Zhejiang Univ, Sch Med, Affiliated Hosp 2, Inst Canc,China Natl Minist Educ,Key Lab Canc Pre, Hangzhou 310009, Zhejiang, Peoples R China
[2] Zhejiang Univ, Sch Med, Collaborat Innovat Ctr Diag & Treatment Infect Di, ZJU UCLA Joint Ctr Med Educ & Res, Hangzhou 310058, Zhejiang, Peoples R China
[3] Univ Calif Los Angeles, David Geffen Sch Med, Dept Mol & Med Pharmacol, Los Angeles, CA 90095 USA
[4] Zhejiang Univ, Sch Med, Res Ctr Infect & Immun, Hangzhou 310058, Zhejiang, Peoples R China
来源：
EMERGING MICROBES & INFECTIONS | 2015年 / 4卷
基金：
中国国家自然科学基金;
关键词：
adaptive immunity; EBV; immune evasion; innate immunity; NPC; NASOPHARYNGEAL CARCINOMA-CELLS; REGULATORY T-CELLS; MEMBRANE-PROTEIN; NF-KAPPA-B; ANTIGEN-PROCESSING FUNCTION; BURKITTS-LYMPHOMA CELLS; CLASS-II EXPRESSION; COMPLEX CLASS-I; DENDRITIC CELLS; LATENT MEMBRANE-PROTEIN-1;
D O I：
10.1038/emi.2015.20
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Epstein-Barr virus (EBV) has been used as a paradigm for studying host-virus interactions, not only because of its importance as a human oncogenic virus associated with several malignancies including nasopharyngeal carcinoma (NPC) but also owing to its sophisticated strategies to subvert the host antiviral responses. An understanding of the interplay between EBV and NPC is critical for the development of EBV-targeted immunotherapy. Here, we summarize the current knowledge regarding the host immune responses and EBV immune evasion mechanisms in the context of NPC.
引用
收藏
页数：9
相关论文
共 176 条
[1]   Exosomal HIF1α supports invasive potential of nasopharyngeal carcinoma-associated LMP1-positive exosomes [J].
Aga, M. ;
Bentz, G. L. ;
Raffa, S. ;
Torrisi, M. R. ;
Kondo, S. ;
Wakisaka, N. ;
Yoshizaki, T. ;
Pagano, J. S. ;
Shackelford, J. .
ONCOGENE, 2014, 33 (37) :4613-4622
[2]   Viral mechanisms of immune evasion [J].
Alcami, A ;
Koszinowski, UH .
TRENDS IN MICROBIOLOGY, 2000, 8 (09) :410-418
[3]   The Epstein-Barr virus-encoded LMP2A and LMP2B proteins promote epithelial cell spreading and motility [J].
Allen, MD ;
Young, LS ;
Dawson, CW .
JOURNAL OF VIROLOGY, 2005, 79 (03) :1789-1802
[4]  
Altman JD, 2011, J IMMUNOL, V187
[5]   Plasma Epstein-Barr Virus DNA Level Strongly Predicts Survival in Metastatic/Recurrent Nasopharyngeal Carcinoma Treated With Palliative Chemotherapy [J].
An, Xin ;
Wang, Feng-Hua ;
Ding, Pei-Rong ;
Deng, Ling ;
Jiang, Wen-Qi ;
Zhang, Li ;
Shao, Jian-Yong ;
Li, Yu-Hong .
CANCER, 2011, 117 (16) :3750-3757
[6]   Increased CD8+T Cell Response to Epstein-Barr Virus Lytic Antigens in the Active Phase of Multiple Sclerosis [J].
Angelini, Daniela F. ;
Serafini, Barbara ;
Piras, Eleonora ;
Severa, Martina ;
Coccia, Eliana M. ;
Rosicarelli, Barbara ;
Ruggieri, Serena ;
Gasperini, Claudio ;
Buttari, Fabio ;
Centonze, Diego ;
Mechelli, Rosella ;
Salvetti, Marco ;
Borsellino, Giovanna ;
Aloisi, Francesca ;
Battistini, Luca .
PLOS PATHOGENS, 2013, 9 (04)
[7]   The EBV-Encoded dUTPase Activates NF-κB through the TLR2 and MyD88-Dependent Signaling Pathway [J].
Ariza, Maria-Eugenia ;
Glaser, Ronald ;
Kaumaya, Pravin T. P. ;
Jones, Chris ;
Williams, Marshall V. .
JOURNAL OF IMMUNOLOGY, 2009, 182 (02) :851-859
[8]  
BEAULIEU AD, 1995, BLOOD, V86, P2789
[9]   Human CD8+ T cell responses to EBV EBNA1:: HLA class I presentation of the (Gly-Ala)-containing protein requires exogenous processing [J].
Blake, N ;
Lee, S ;
Redchenko, I ;
Thomas, W ;
Steven, N ;
Leese, A ;
Steigerwald-Mullen, P ;
Kurilla, MG ;
Frappier, L ;
Rickinson, A .
IMMUNITY, 1997, 7 (06) :791-802
[10]   The importance of exogenous antigen in priming the human CD8+ T cell response:: Lessons from the EBV nuclear antigen EBNA1 [J].
Blake, N ;
Haigh, T ;
Shaka'a, G ;
Croom-Carter, D ;
Rickinson, A .
JOURNAL OF IMMUNOLOGY, 2000, 165 (12) :7078-7087
12345678910