Efficient solid-phase synthesis of 1,3,4-trisubstituted β-thiolactams

被引：17

作者：

Méndez, L ^{[1
]}

Delpiccolo, CML ^{[1
]}

Mata, EG ^{[1
]}

机构：

[1] Univ Nacl Rosario, Fac Ciencias Bioquim & Farmaceut, CONICET, Inst Quim Organ Sintesis,UNR, RA-2000 Rosario, Santa Fe, Argentina

来源：

SYNLETT | 2005年 / 10期

关键词：

solid-phase synthesis; beta-thiolactams; Lawesson's reagent; beta-lactams; combinatorial chemistry;

D O I：

10.1055/s-2005-869855

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient solid-phase synthesis of a series of 1,3,4-trisubstituted beta-thiolactams is described. The key reaction, a direct thionation of polymer-supported beta-lactams, was carried out using the Lawesson's reagent to give beta-thiolactams in good overall yields.

引用

页码：1563 / 1566

页数：4

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