Altered resting-state thalamo-occipital functional connectivity is associated with cognition in isolated rapid eye movement sleep behavior disorder

被引：53

作者：

Byun, Jung-Ick ^{[1
]}

Kim, Hyun-Woo ^{[2
]}

Kang, Hyejin ^{[3
,4
]}

Cha, Kwang Su ^{[2
]}

Sunwoo, Jun-Sang ^{[5
]}

Shin, Jung-Won ^{[6
]}

Moon, Jangsup ^{[2
,7
]}

Lee, Soon-Tae ^{[2
]}

Jung, Keun-Hwa ^{[2
]}

Chu, Kon ^{[2
]}

Kim, Manho ^{[2
,8
]}

Shin, Won Chul ^{[1
]}

Lee, Dong Soo ^{[3
,9
]}

Schenck, Carlos H. ^{[10
]}

Lee, Sang Kun ^{[2
]}

Jung, Ki-Young ^{[2
]}

机构：

[1] Kyung Hee Univ, Kyung Hee Univ Hosp Gangdong, Dept Neurol, Coll Med, Seoul, South Korea

[2] Seoul Natl Univ, Seoul Natl Univ Hosp, Dept Neurol, Coll Med, Seoul, South Korea

[3] Seoul Natl Univ, Dept Nucl Med, Coll Med, Seoul, South Korea

[4] BK21 Plus Global Translat Res Mol Med & Biopharma, Seoul, South Korea

[5] Seoul Natl Univ Hosp, Dept Neurosurg, Seoul, South Korea

[6] CHA Univ, CHA Bundang Med Ctr, Dept Neurol, Seongnam, South Korea

[7] Seoul Natl Univ Hosp, Rare Dis Ctr, Seoul, South Korea

[8] Seoul Natl Univ, Dementia Res Ctr, Seoul, South Korea

[9] Seoul Natl Univ, Grad Sch Convergence Sci & Technol, Dept Mol Med & Biopharmaceut Sci, Seoul, South Korea

[10] Univ Minnesota, Minnesota Reg Sleep Disorders Ctr, Hennepin Cty Med Ctr, Dept Psychiat,Med Sch, Minneapolis, MN USA

来源：

SLEEP MEDICINE | 2020年 / 69卷

基金：

新加坡国家研究基金会;

关键词：

REM sleep behavior disorder; Functional brain imaging; Neuroimaging; Cognitive function; WORD FORM AREA; KOREAN VERSION; IMPAIRMENT; DISEASE; ALZHEIMERS; CERAD; CONSORTIUM; ESTABLISH; REGISTRY;

D O I：

10.1016/j.sleep.2020.01.010

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Objective: Isolated rapid eye movement sleep behavior disorder (iRBD) patients are at risk of cognitive impairments, however the underlying mechanism is still unclear. This study aimed to evaluate thalamocortical functional connectivity (FC) using resting-state functional magnetic resonance imaging (fMRI) and its correlation with cognitive dysfunction in patients with iRBD. Methods: A total 37 polysomnographies (PSGs) confirmed iRBD patients and 15 age-sex matched controls underwent resting-state fMRI and comprehensive neuropsychological assessment. Thalamo-cortical FC was evaluated by using seed-to voxel analysis and was compared between the iRBD and controls. Correlation between the average value of significant clusters and cognitive function scores in iRBD were calculated. Results: Compared to the control subjects, patients with iRBD patients showed cognitive decline in word list recognition (p = 0.016), and constructional recall (p = 0.044). The FC analysis showed increased FC between the left thalamus and occipital regions including the right cuneal cortex, left fusiform gyrus and lingual gyrus (cluster level p < 0.05, corrected for false discovery rate). The averaged thalamo-fusiform FC value positively correlated with word list recognition after adjusting for age and sex (adjusted r = 0.347, p = 0.041). Conclusion: Thalamic resting state FC is altered in iRBD patients and is associated with the cognitive function. Enhancement of the thalamo-occipital FC may reflect a compensatory mechanism for cognitive impairment in iRBD. (C) 2020 Elsevier B.V. All rights reserved.

引用

页码：198 / 203

页数：6

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