Co-delivery of paclitaxel and doxorubicin using polypeptide-engineered nanogels for combination therapy of tumor

被引:8
|
作者
Yang, Jie [1 ]
Jin, Rui-Mei [2 ]
Wang, Shen-Yan [3 ,4 ]
Xie, Xiao-Ting [1 ]
Hu, Wei [3 ,4 ]
Tang, Hong-Feng [3 ,4 ]
Liu, Bo [1 ]
机构
[1] Huazhong Univ Sci & Technol, Coll Life Sci & Technol, Britton Chance Ctr Biomed Photon,Hubei Bioinforma, Dept Biomed Engn,Wuhan Natl Lab Optoelect, Wuhan 430074, Hubei, Peoples R China
[2] Zhengzhou Univ, Sch Life Sci, 100 Sci Rd, Zhengzhou 450001, Peoples R China
[3] Wuhan Donghu Univ, Coll Nursing & Hlth Management, Innovat Inst Biomed Mat, Wuhan 430212, Hubei, Peoples R China
[4] Wuhan Donghu Univ, Coll Life Sci & Chem, Wuhan 430212, Peoples R China
基金
中国国家自然科学基金;
关键词
co-delivery; engineered polypeptide; nanogel; chemotherapy; synergistic therapy; CANCER;
D O I
10.1088/1361-6528/ac46b4
中图分类号
TB3 [工程材料学];
学科分类号
0805 ; 080502 ;
摘要
Loading of chemotherapeutic agents into nanoparticles has been demonstrated to be an effective strategy for cancer therapy. However, simultaneous delivery of different functional drugs to tumor sites for chemotherapy still remains challenging. In this study, nanogels formed by an engineered coiled-coil polypeptide PC(10)A were designed and prepared as a carrier for co-delivery of paclitaxel (PTX) and doxorubicin (DOX) through ultrasonic treatment and electrostatic adsorption. The drug loading content and encapsulation efficiency of PTX and DOX in the PC(10)A/PTX/DOX nanogels were 5.98 wt%, 70 wt%, and 8.55 wt%, 83 wt%, respectively. Because the polypeptide PC(10)A was non-toxic and biodegradable, the PC(10)A/PTX/DOX nanogels exhibited good biocompatibility. The in vitro and in vivo antitumor experiments showed that the PC(10)A/PTX/DOX nanogels possessed obviously synergistic therapy effect of tumors and lower side effects compared with free PTX/DOX. Therefore, the PC(10)A/PTX/DOX nanogels are promising to provide a new strategy for combination therapy of different functional drugs.
引用
收藏
页数:10
相关论文
共 50 条
  • [31] Co-delivery of doxorubicin and DNAzyme using ZnO@polydopamine core-shell nanocomposites for chemo/gene/photothermal therapy
    Liu, Miao
    Peng, Ying
    Nie, Yunbo
    Liu, Peng
    Hu, Shuo
    Ding, Jinsong
    Zhou, Wenhu
    ACTA BIOMATERIALIA, 2020, 110 : 242 - 253
  • [32] Co-Delivery of Paclitaxel and Interleukin-12 Regulating Tumor Microenvironment for Cancer Immunochemotherapy
    Hu, Qian
    Shang, Lihuan
    Wang, Mengmeng
    Tu, Kun
    Hu, Mei
    Yu, Yulin
    Xu, Mingwang
    Kong, Li
    Guo, Yuanyuan
    Zhang, Zhiping
    ADVANCED HEALTHCARE MATERIALS, 2020, 9 (10)
  • [33] A novel multi stimuli-responsive PEGylated hybrid gold/nanogels for co-delivery of doxorubicin and 6-mercaptopurine
    Ghorbani, Marjan
    Hamishehkar, Hamed
    MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 2018, 92 : 599 - 611
  • [34] Amphiphilic star copolymers-mediated co-delivery of doxorubicin and avasimibe for effective combination chemotherapy
    Bai, Ting
    Zhu, Bobo
    Du, Zhaoyi
    Shi, Junling
    Shao, Dongyan
    Kong, Jie
    JOURNAL OF MATERIALS SCIENCE, 2020, 55 (22) : 9525 - 9537
  • [35] Co-delivery of plasmid DNA and doxorubicin by solid lipid nanoparticles for lung cancer therapy
    Han, Yiqun
    Zhang, Peng
    Chen, Yuanyuan
    Sun, Jiping
    Kong, Fansheng
    INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2014, 34 (01) : 191 - 196
  • [36] The targeted co-delivery of DNA and doxorubicin to tumor cells via multifunctional PEI-PEG based nanoparticles
    Liu, Chunxi
    Liu, Fengxi
    Feng, Lixia
    Li, Min
    Zhang, Jian
    Zhang, Na
    BIOMATERIALS, 2013, 34 (10) : 2547 - 2564
  • [37] Synergistic combination therapy of lung cancer: Cetuximab functionalized nanostructured lipid carriers for the co-delivery of paclitaxel and 5-Demethylnobiletin
    Guo, Shenghu
    Zhang, Yuehua
    Wu, Zheng
    Zhang, Lei
    He, Dongwei
    Li, Xing
    Wang, Zhiyu
    BIOMEDICINE & PHARMACOTHERAPY, 2019, 118
  • [38] Combination of tumour-infarction therapy and chemotherapy via the co-delivery of doxorubicin and thrombin encapsulated in tumour-targeted nanoparticles
    Li, Suping
    Zhang, Yinlong
    Ho, Shih-Hsin
    Li, Bozhao
    Wang, Meifang
    Deng, Xiongwei
    Yang, Na
    Liu, Guangna
    Lu, Zefang
    Xu, Junchao
    Shi, Quanwei
    Han, Jing-Yan
    Zhang, Lirong
    Wu, Yan
    Zhao, Yuliang
    Nie, Guangjun
    NATURE BIOMEDICAL ENGINEERING, 2020, 4 (07) : 732 - 742
  • [39] Folate-conjugated and pH-triggered doxorubicin and paclitaxel co-delivery micellar system for targeted anticancer drug delivery
    Niu, Lijing
    Zhu, Feiyan
    Li, Bowen
    Zhao, Lingling
    Liang, Hongze
    Yan, Yinghua
    Tan, Hui
    MATERIALS CHEMISTRY FRONTIERS, 2018, 2 (08) : 1529 - 1538
  • [40] Co-delivery of doxorubicin and paclitaxel with linear-dendritic block copolymer for enhanced anti-cancer efficacy
    Zhang Yu
    Xiao ChunSheng
    Li MingQiang
    Ding JianXun
    Yang ChenGuang
    Zhuang XiuLi
    Chen XueSi
    SCIENCE CHINA-CHEMISTRY, 2014, 57 (04) : 624 - 632