Whole Genome Sequencing in the Management of Non-Tuberculous Mycobacterial Infections

被引：26

作者：

Dohal, Matus ^{[1
]}

Porvaznik, Igor ^{[2
,3
]}

Solovic, Ivan ^{[2
,3
]}

Mokry, Juraj ^{[1
]}

机构：

[1] Comenius Univ, Jessenius Fac Med, Biomed Ctr Martin, Dept Pharmacol, Martin 03601, Slovakia

[2] Natl Inst TB Lung Dis & Thorac Surg, Vysne Hagy 05981, Slovakia

[3] Catholic Univ, Fac Hlth, Ruzomberok 03401, Slovakia

来源：

MICROORGANISMS | 2021年 / 9卷 / 11期

关键词：

whole-genome sequencing; non-tuberculous mycobacteria; diagnostics; HEATER-COOLER UNITS; CYSTIC-FIBROSIS; LUNG TRANSPLANTATION; PULMONARY INFECTION; CHELONAE INFECTION; CARDIAC-SURGERY; ABSCESSUS; DISEASE; DIAGNOSIS; CHIMERA;

D O I：

10.3390/microorganisms9112237

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Infections caused by non-tuberculous mycobacteria (NTM) have been a public health problem in recent decades and contribute significantly to the clinical and economic burden globally. The diagnosis of infections is difficult and time-consuming and, in addition, the conventional diagnostics tests do not have sufficient discrimination power in species identification due to cross-reactions and not fully specific probes. However, technological advances have been made and the whole genome sequencing (WGS) method has been shown to be an essential part of routine diagnostics in clinical mycobacteriology laboratories. The use of this technology has contributed to the characterization of new species of mycobacteria, as well as the identification of gene mutations encoding resistance and virulence factors. Sequencing data also allowed to track global outbreaks of nosocomial NTM infections caused by M. abscessus complex and M. chimaera. To highlight the utility of WGS, we summarize recent scientific studies on WGS as a tool suitable for the management of NTM-induced infections in clinical practice.

引用

页数：15

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