Lipids at membrane contact sites: cell signaling and ion transport

被引：69

作者：

Muallem, Shmuel ^{[1
]}

Chung, Woo Young ^{[1
]}

Jha, Archana ^{[1
]}

Ahuja, Malini ^{[1
]}

机构：

[1] NIDCR, Epithelial Signaling & Transport Sect, Bethesda, MD 20892 USA

来源：

EMBO REPORTS | 2017年 / 18卷 / 11期

关键词：

contact sites; ion transport; lipid transfer; signaling; ENDOPLASMIC-RETICULUM; PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE; ER-PM; MITOFUSIN; CHOLESTEROL-BINDING; POTASSIUM CHANNELS; TRANSFER PROTEINS; STRUCTURAL BASIS; TRPC CHANNELS; K+ CHANNEL;

D O I：

10.15252/embr.201744331

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Communication between organelles is essential to coordinate cellular functions and the cell's response to physiological and pathological stimuli. Organellar communication occurs at membrane contact sites (MCSs), where the endoplasmic reticulum (ER) membrane is tethered to cellular organelle membranes by specific tether proteins and where lipid transfer proteins and cell signaling proteins are located. MCSs have many cellular functions and are the sites of lipid and ion transfer between organelles and generation of second messengers. This review discusses several aspects of MCSs in the context of lipid transfer, formation of lipid domains, generation of Ca2+ and cAMP second messengers, and regulation of ion transporters by lipids.

引用

页码：1893 / 1904

页数：12

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