Targeting Non-Oncogene Addiction: Focus on Thyroid Cancer

被引:6
作者
Anania, Maria Chiara [1 ]
Di Marco, Tiziana [1 ]
Mazzoni, Mara [1 ]
Greco, Angela [1 ]
机构
[1] Fdn IRCCS Ist Nazl Tumori, Mol Mech Unit, Dept Res, I-20133 Milan, Italy
关键词
non-oncogene addiction; thyroid cancer; functional screening; non-oncogenes; tumor vulnerabilities; therapeutic targets; BREAST-CANCER; THERAPEUTIC TARGET; DOWN-REGULATION; TUMOR-CELLS; RNAI SCREEN; PROTEIN; CARCINOMA; GENE; EXPRESSION; PAPILLARY;
D O I
10.3390/cancers12010129
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Thyroid carcinoma (TC) is the most common malignancy of endocrine organs with an increasing incidence in industrialized countries. The majority of TC are characterized by a good prognosis, even though cases with aggressive forms not cured by standard therapies are also present. Moreover, target therapies have led to low rates of partial response and prompted the emergence of resistance, indicating that new therapies are needed. In this review, we summarize current literature about the non-oncogene addiction (NOA) concept, which indicates that cancer cells, at variance with normal cells, rely on the activity of genes, usually not mutated or aberrantly expressed, essential for coping with the transformed phenotype. We highlight the potential of non-oncogenes as a point of intervention for cancer therapy in general, and present evidence for new putative non-oncogenes that are essential for TC survival and that may constitute attractive new therapeutic targets.
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页数:20
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