Recombinant West Nile virus envelope protein E and domain III expressed in insect larvae protects mice against West Nile disease

被引：24
作者：
Alonso-Padilla, Julio [1 ]
Jimenez de Oya, Nereida [1 ]
Blazquez, Ana-Belen [1 ]
Escribano-Romero, Estela [1 ]
Escribano, Jose M. [1 ]
Saiz, Juan-Carlos [1 ]
机构：
[1] Inst Nacl Invest & Tecnol Agr & Alimentaria INIA, Dept Biotechnol, Madrid 28040, Spain
来源：
VACCINE | 2011年 / 29卷 / 09期
关键词：
Vaccine; Passive immune transfer; Insect biofactories; HEPATITIS-E VIRUS; CD8(+) T-CELLS; ENCEPHALITIS-VIRUS; DISSEMINATED INFECTION; VACCINE DEVELOPMENT; ANTIBODIES; IMMUNIZATION; DIAGNOSIS; IMMUNITY; BACULOVIRUS;
D O I：
10.1016/j.vaccine.2010.12.081
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
In this study, West Nile virus (WNV) envelope (rE) protein and its domain III (rDIII) were efficiently expressed in a cost-effective system based on insect larvae as non-fermentative living biofactories. Mice immunized with the partially purified rE or rDIII elicited high antibodies titers that neutralized viral infectivity in cell culture and in suckling mice. All vaccinated animals were fully protected when challenged with neurovirulent WNV NY99. Passive transfer of protective antibodies from immunized mothers to their offspring occurred both by transplacental and lactation routes. These results indicate that the insect-derived antigens tested may constitute potential vaccine candidates to be further evaluated. (C) 2010 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1830 / 1835
页数：6
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