Methamphetamine-induced increase in striatal NF-κB DNA-binding activity is attenuated in superoxide dismutase transgenic mice

被引：49
|
作者：
Asanuma, M [1 ]
Cadet, JL [1 ]
机构：
[1] NIDA, Intramural Res Program, Mol Neuropsychiat Sect, NIH, Baltimore, MD USA
来源：
MOLECULAR BRAIN RESEARCH | 1998年 / 60卷 / 02期
关键词：
transcription factor; NF-kappa B; methamphetamine; superoxide dismutase; transgenic mice; reactive oxygen species;
D O I：
10.1016/S0169-328X(98)00188-0
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Methamphetamine injection (X4 with 2-h interval) caused dose-dependent activation of striatal NF-kappa B activity. Striatal NF-kappa B binding increased significantly at 1-3 h after the last injection of methamphetamine (10 mg/kg, i.p. X4). This induction of striatal NF-kappa B activity was significantly attenuated in Cu,Zn-superoxide dismutase transgenic mice in a gene dosage-dependent fashion. The present results suggest that reactive oxygen species generated by methamphetamine injections can activate striatal NF-kappa B DNA-binding during this drug-induced toxic process. (C) 1998 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：305 / 309
页数：5
相关论文
共 50 条
  • [41] Limited availability of l-arginine increases DNA-binding activity of NF-κB and contributes to regulation of iNOS expression
    Guido Kagemann
    Helmut Sies
    Oliver Schnorr
    Journal of Molecular Medicine, 2007, 85 : 723 - 732
  • [42] Limited availability of L-arginine increases DNA-binding activity of NF-κB and contributes to regulation of iNOS expression
    Kagemann, Guido
    Sies, Helmut
    Schnorr, Oliver
    JOURNAL OF MOLECULAR MEDICINE-JMM, 2007, 85 (07): : 723 - 732
  • [43] Stress-induced enhancement of NF-κB DNA-binding in the peripheral blood leukocyte pool:: effects of lymphocyte redistribution
    Richlin, VA
    Arevalo, JMG
    Zack, JA
    Cole, SW
    BRAIN BEHAVIOR AND IMMUNITY, 2004, 18 (03) : 231 - 237
  • [44] Sustained elevation of NF-κB DNA binding activity in radiation-induced lung damage in rats
    Haase, MG
    Klawitter, A
    Geyer, P
    Alheit, H
    Baumann, M
    Kriegel, TM
    Kasper, M
    Baretton, GB
    INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 2003, 79 (11) : 863 - 877
  • [45] Melatonin Protects Methamphetamine-Induced Neuroinflammation Through NF-κB and Nrf2 Pathways in Glioma Cell Line
    Jumnongprakhon, Pichaya
    Govitrapong, Piyarat
    Tocharus, Chainarong
    Pinkaew, Decha
    Tocharus, Jiraporn
    NEUROCHEMICAL RESEARCH, 2015, 40 (07) : 1448 - 1456
  • [46] Melatonin Protects Methamphetamine-Induced Neuroinflammation Through NF-κB and Nrf2 Pathways in Glioma Cell Line
    Pichaya Jumnongprakhon
    Piyarat Govitrapong
    Chainarong Tocharus
    Decha Pinkaew
    Jiraporn Tocharus
    Neurochemical Research, 2015, 40 : 1448 - 1456
  • [47] The Velvet Family of Fungal Regulators Contains a DNA-Binding Domain Structurally Similar to NF-κB
    Ahmed, Yasar Luqman
    Gerke, Jennifer
    Park, Hee-Soo
    Bayram, Oezguer
    Neumann, Piotr
    Ni, Min
    Dickmanns, Achim
    Kim, Sun Chang
    Yu, Jae-Hyuk
    Braus, Gerhard H.
    Ficner, Ralf
    PLOS BIOLOGY, 2013, 11 (12)
  • [48] A plasmid-based display system utilising the DNA-binding protein, NF-κB.
    Blackburn, JM
    Hart, DJ
    Speight, RE
    Sutherland, JD
    FASEB JOURNAL, 1997, 11 (09): : A1158 - A1158
  • [49] DNA-binding activity of NF-κB and phosphorylation of p65 are induced by N-acetylcysteine through phosphatidylinositol (PI) 3-kinase
    Liu, Jiqin
    Yoshida, Yasuhiro
    Yamashita, Uki
    MOLECULAR IMMUNOLOGY, 2008, 45 (15) : 3984 - 3989
  • [50] NF-κB is required for cytokine-induced manganese superoxide dismutase expression in insulin-producing cells
    Darville, MI
    Ho, YS
    Eizirik, DL
    ENDOCRINOLOGY, 2000, 141 (01) : 153 - 162
12345