Methamphetamine-induced increase in striatal NF-κB DNA-binding activity is attenuated in superoxide dismutase transgenic mice

被引：49
|
作者：
Asanuma, M [1 ]
Cadet, JL [1 ]
机构：
[1] NIDA, Intramural Res Program, Mol Neuropsychiat Sect, NIH, Baltimore, MD USA
来源：
MOLECULAR BRAIN RESEARCH | 1998年 / 60卷 / 02期
关键词：
transcription factor; NF-kappa B; methamphetamine; superoxide dismutase; transgenic mice; reactive oxygen species;
D O I：
10.1016/S0169-328X(98)00188-0
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Methamphetamine injection (X4 with 2-h interval) caused dose-dependent activation of striatal NF-kappa B activity. Striatal NF-kappa B binding increased significantly at 1-3 h after the last injection of methamphetamine (10 mg/kg, i.p. X4). This induction of striatal NF-kappa B activity was significantly attenuated in Cu,Zn-superoxide dismutase transgenic mice in a gene dosage-dependent fashion. The present results suggest that reactive oxygen species generated by methamphetamine injections can activate striatal NF-kappa B DNA-binding during this drug-induced toxic process. (C) 1998 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：305 / 309
页数：5
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