The Role of Gut Dysbiosis in Acute-on-Chronic Liver Failure

被引：13

作者：

Kim, Sung-Eun ^{[1
,2
]}

Park, Ji Won ^{[1
,2
]}

Kim, Hyung Su ^{[1
,2
]}

Jang, Myoung-Kuk ^{[1
,2
]}

Suk, Ki Tae ^{[1
,2
]}

Kim, Dong Joon ^{[1
,2
]}

机构：

[1] Hallym Univ, Dept Internal Med, Coll Med, Chunchon 24252, South Korea

[2] Hallym Univ, Inst Liver & Digest Dis, Chunchon 24252, South Korea

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2021年 / 22卷 / 21期

基金：

新加坡国家研究基金会;

关键词：

cirrhosis; gut microbiome; alcoholic liver disease; acute-on-chronic liver failure; ALCOHOL-USE DISORDERS; HIGH-FAT DIET; DECOMPENSATED CIRRHOSIS; INTESTINAL MICROBIOTA; HEPATIC-ENCEPHALOPATHY; BILE-ACIDS; BACTERIAL; INFLAMMATION; TRANSLOCATION; DISEASE;

D O I：

10.3390/ijms222111680

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Acute-on-chronic liver failure (ACLF) is an important syndrome of liver failure that has a high risk of short-term mortality in patients with chronic liver disease. The development of ACLF is associated with proinflammatory precipitating events, such as infection, alcoholic hepatitis, and intense systemic inflammation. Recently, the role of the gut microbiome has increasingly emerged in human health and disease. Additionally, the gut microbiome might have a major role in the development of liver disease. In this review, we examine evidence to support the role of gut dysbiosis in cirrhosis and ACLF. Additionally, we explore the mechanism by which the gut microbiome contributes to the development of ACLF, with a focus on alcohol-induced liver disease.

引用

页数：18

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