Change in Antimicrobial Susceptibility of Skin-Colonizing Staphylococcus aureus in Korean Patients with Atopic Dermatitis during Ten-Year Period

被引:10
作者
Park, Jung-Min [1 ]
Jo, Ju-Hyun [2 ]
Jin, Hyunju [1 ]
Ko, Hyun-Chang [1 ,3 ]
Kim, Moon-Bum [1 ,3 ]
Kim, Jung-Min [4 ]
Kim, Do-Won [5 ]
Jang, Ho-Sun [6 ]
Kim, Byung-Soo [1 ,3 ]
机构
[1] Pusan Natl Univ, Sch Med, Dept Dermatol, 179 Gudeok Ro, Busan 49241, South Korea
[2] Pusan Natl Univ Hosp, Bon Dermatol Clin, Busan, South Korea
[3] Pusan Natl Univ Hosp, Biomed Res Inst, Busan, South Korea
[4] Kyungpook Natl Univ, Sch Med, Dept Microbiol, Deagu, South Korea
[5] Kyungpook Natl Univ, Sch Med, Dept Dermatol, Deagu, South Korea
[6] Jang Ho Sun Dermatol Clin, Busan, South Korea
关键词
Anti-bacterial agent; Antimicrobial resistance; Antimicrobial susceptibility; Atopic dermatitis; Staphylococcus aureus; ACQUIRED METHICILLIN-RESISTANT; SOFT-TISSUE INFECTIONS; BACTERIAL PATHOGENS; CUTANEOUS INFECTIONS; CHILDREN; COLONIZATION; PREVALENCE; FREQUENCY; PATTERNS; STRAINS;
D O I
10.5021/ad.2016.28.4.470
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Background: A small subset of adolescents atopic dermatitis (AD) tends to persist. This also leads to get more antibiotics exposure with advancing years. Antibiotic resistance has been regarded as a serious problem during Staphylococcus aureus treatment, especially methicillin-resistant S. aureus (MRSA). Objective: It was investigated the S. aureus colonization frequency in the skin lesions and anterior nares of adolescent AD patients and evaluated the changes in S. aureus antimicrobial susceptibility for years. Methods: Patients who visited our clinic from September 2003 to August 2005 were classified into group A, and patients who visited from August 2010 to March 2012 were classified into group B. To investigate the differences with regard to patients' age and disease duration, the patients were subdivided into groups according to age. Lesional and nasal specimens were examined. Results: Among the 295 AD patients, the total S. aureuscolonization rate in skin lesions was 66.9% (95/142) for group A and 78.4% (120/153) for group B. No significant changes in the systemic antimicrobial susceptibilities of S. aureusstrains isolated from adolescent AD patients were observed during about 10-year period. The increased trend of MRSA isolation in recent adolescent AD outpatients suggest that the community including school could be the source of S. aureusantibiotic resistance and higher fusidicacid resistance rates provides evidence of imprudent topical use. Conclusion: Relatively high MRSA isolation and fusidic acid resistance rates in recent AD patients suggest that the community harbors antibiotic-resistant S. aureus.
引用
收藏
页码:470 / 478
页数:9
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