Copper-Catalyzed N-Directed Distal C(sp3)-H Sulfonylation and Thiolation with Sulfinate Salts

被引：29

作者：

Chen, Guang-Le ^{[1
,2
]}

He, Shi-Hui ^{[1
,2
]}

Cheng, Liang ^{[1
,2
]}

Liu, Feng ^{[1
,2
,3
]}

机构：

[1] Soochow Univ, Coll Pharmaceut Sci, Jiangsu Key Lab Neuropsychiat Dis, Suzhou 215123, Jiangsu, Peoples R China

[2] Soochow Univ, Coll Pharmaceut Sci, Dept Med Chem, Suzhou 215123, Jiangsu, Peoples R China

[3] Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Organofluorine Chem, Shanghai 200032, Peoples R China

来源：

ORGANIC LETTERS | 2021年 / 23卷 / 21期

关键词：

SULFUR;

D O I：

10.1021/acs.orglett.1c03075

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We herein report a selective and catalytic C(sp(3))-H functionalization approach to access amines bearing organo-sulfonyl and organo-thiol groups. This reaction proceeds through a cascade process of N-radical formation, alkyl radical formation via 1,5-HAT, and C-S bond formation, thereby offering a series of functionalized amines. This method could enable primary, secondary, and tertiary C(sp(3))-H sulfonylation and thiolation and also exhibits good functional group tolerance.

引用

页码：8338 / 8342

页数：5

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