Suzuki coupling of aryl chlorides with phenylboronic acid in water, using microwave heating with simultaneous cooling

被引：245

作者：

Arvela, RK ^{[1
]}

Leadbeater, NE ^{[1
]}

机构：

[1] Univ Connecticut, Dept Chem, Unit 3060, Storrs, CT 06269 USA

来源：

ORGANIC LETTERS | 2005年 / 7卷 / 11期

关键词：

D O I：

10.1021/ol0503384

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We present here a methodology for the Suzuki coupling of aryl chlorides with phenylboronic acid using Pd/C as a catalyst, water as a solvent, and microwave heating. We show that simultaneous cooling in conjunction with microwave heating prolongs the lifetime of the aryl chloride substrates during the course of the reaction and, as a result, yields of the desired biaryl as well as overall recovery of material can be increased.

引用

页码：2101 / 2104

页数：4

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