Tuberculosis Immunity: Opportunities from Studies with Cattle

被引：50

作者：

RayWaters, W. ^{[1
]}

Palmer, Mitchell V. ^{[1
]}

Thacker, Tyler C. ^{[1
]}

Davis, William C. ^{[2
]}

Sreevatsan, Srinand ^{[3
,4
]}

Coussens, Paul ^{[5
]}

Meade, Kieran G. ^{[6
]}

Hope, Jayne C. ^{[7
]}

Estes, D. Mark ^{[8
]}

机构：

[1] ARS, Natl Anim Dis Ctr, USDA, Ames, IA 50010 USA

[2] Washington State Univ, Coll Vet Med, Dept Vet Microbiol & Pathol, Pullman, WA 99164 USA

[3] Univ Minnesota, Dept Vet Populat Med, St Paul, MN 55108 USA

[4] Univ Minnesota, Dept Vet Biomed Sci, St Paul, MN 55108 USA

[5] Michigan State Univ, Dept Anim Sci, E Lansing, MI 48824 USA

[6] BT55&GE Co, Anim Biosci Ctr, TEAGASC, Grange, Meath, Ireland

[7] Inst Anim Hlth, Livestock Dis Programme, Compton RG20 7NN, England

[8] Univ Texas Med Branch, Dept Microbiol & Immunol, Galveston, TX 77555 USA

来源：

CLINICAL & DEVELOPMENTAL IMMUNOLOGY | 2011年

关键词：

MYCOBACTERIUM-BOVIS BCG; DELTA T-CELLS; BLOOD MONONUCLEAR-CELLS; NATURAL-KILLER-CELLS; MONOCYTE-DERIVED MACROPHAGES; CYTOKINE GENE-EXPRESSION; BACILLE CALMETTE-GUERIN; INFECTED CATTLE; GAMMA-INTERFERON; IN-VITRO;

D O I：

10.1155/2011/768542

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Mycobacterium tuberculosis and M. bovis share >99% genetic identity and induce similar host responses and disease profiles upon infection. There is a rich history of codiscovery in the development of control measures applicable to both human and bovine tuberculosis (TB) including skin-testing procedures, M. bovis BCG vaccination, and interferon-gamma release assays. The calf TB infection model offers several opportunities to further our understanding of TB immunopathogenesis. Recent observations include correlation of central memory immune responses with TB vaccine efficacy, association of SIRP alpha(+) cells in ESAT-6:CFP10-elicited multinucleate giant cell formation, early gamma delta T cell responses to TB, antimycobacterial activity of memory CD4(+) T cells via granulysin production, association of specific antibody with antigen burden, and suppression of innate immune gene expression in infected animals. Partnerships teaming researchers with veterinary and medical perspectives will continue to provide mutual benefit to TB research in man and animals.

引用

页数：11

共 120 条

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