Pathophysiology of Acute and Chronic Right Heart Failure

被引：53
作者：
Thandavarayan, Rajarajan A. [1 ]
Chitturi, Kalyan R. [1 ]
Guha, Ashrith [1 ]
机构：
[1] Houston Methodist DeBakey Heart & Vasc Ctr, 6550 Fannin St, Houston, TX 77030 USA
来源：
CARDIOLOGY CLINICS | 2020年 / 38卷 / 02期
关键词：
Right heart failure; Pulmonary hypertension; Hypertrophy; Metabolism; Angiogenesis; Inflammation; Mechanical circulatory support; PULMONARY ARTERIAL-HYPERTENSION; RIGHT-VENTRICULAR FUNCTION; LARGE ANIMAL-MODEL; PRESSURE-OVERLOAD; VOLUME-OVERLOAD; TRANSCRIPTIONAL PROFILE; MOLECULAR-MECHANISMS; SCIENTIFIC STATEMENT; MURINE MODEL; EMBOLISM;
D O I：
10.1016/j.ccl.2020.01.009
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Right-sided heart failure (RHF) occurs from impaired contractility of the right ventricle caused by pressure, volume overload, or intrinsic myocardial contractile dysfunction. The development of subclinical right ventricle (RV) dysfunction or overt RHF is a negative prognostic indicator. Recent attention has focused on RV-specific inflammatory growth factors and mediators of myocardial fibrosis to elucidate the mechanisms leading to RHF and potentially guide the development of novel therapeutics. This article focuses on the distinct changes in RV structure, mechanics, and function, as well as molecular and inflammatory mediators involved in the pathophysiology of acute and chronic RHF.
引用
收藏
页码：149 / +
页数：13
相关论文
共 87 条
  • [1] Acclimatization to chronic hypobaric hypoxia is associated with a differential transcriptional profile between the right and left ventricle
    Adrogue, JV
    Sharma, S
    Ngumbela, K
    Essop, MF
    Taegtmeyer, H
    [J]. MOLECULAR AND CELLULAR BIOCHEMISTRY, 2005, 278 (1-2) : 71 - 78
  • [2] Age-Dependent Effect of Pediatric Cardiac Progenitor Cells After Juvenile Heart Failure
    Agarwal, Udit
    Smith, Amanda W.
    French, Kristin M.
    Boopathy, Archana V.
    George, Alex
    Trac, David
    Brown, Milton E.
    Shen, Ming
    Jiang, Rong
    Fernandez, Janet D.
    Kogon, Brian E.
    Kanter, Kirk R.
    Alsoufi, Baahaldin
    Wagner, Mary B.
    Platt, Manu O.
    Davis, Michael E.
    [J]. STEM CELLS TRANSLATIONAL MEDICINE, 2016, 5 (07) : 883 - 892
  • [3] Pressure overload induced right ventricular remodeling is not attenuated by the anti-fibrotic agent pirfenidone
    Andersen, Stine
    Axelsen, Julie Birkmose
    Ringgaard, Steffen
    Nyengaard, Jens Randel
    Nielsen, Signe Holm
    Genovese, Federica
    Karsdal, Morten Asser
    Hyldebrandt, Janus Adler
    Sorensen, Charlotte Brandt
    de Man, Frances S.
    Bogaard, Harm Jan
    Nielsen-Kudsk, Jens Erik
    Andersen, Asger
    [J]. PULMONARY CIRCULATION, 2019, 9 (02)
  • [4] Avazmohammadi R, 2017, APL BIOENG, V1, DOI 10.1063/1.5011639
  • [5] Differential responses of the right ventricle to abnormal loading conditions in mice: pressure vs. volume load
    Bartelds, Beatrijs
    Borgdorff, Marinus A.
    Smit-van Oosten, Annemiek
    Takens, Janny
    Boersma, Bibiche
    Nederhoff, Marcel G.
    Elzenga, Nynke J.
    van Gilst, Wiek H.
    De Windt, Leon J.
    Berger, Rolf M. F.
    [J]. EUROPEAN JOURNAL OF HEART FAILURE, 2011, 13 (12) : 1275 - 1282
  • [6] Congenital Heart Disease in the Older Adult A Scientific Statement From the American Heart Association
    Bhatt, Ami B.
    Foster, Elyse
    Kuehl, Karen
    Alpert, Joseph
    Brabeck, Stephen
    Crumb, Stephen
    Davidson, William R., Jr.
    Earing, Michael G.
    Ghoshhajra, Brian B.
    Karamlou, Tara
    Mital, Seema
    Ting, Jennifer
    Tseng, Zian H.
    [J]. CIRCULATION, 2015, 131 (21) : 1884 - 1931
  • [7] RETRACTED: Nitric Oxide Synthase 2 Induction Promotes Right Ventricular Fibrosis (Retracted Article)
    Boehm, Mario
    Novoyatleva, Tatyana
    Kojonazarov, Baktybek
    Veit, Florian
    Weissmann, Norbert
    Ghofrani, Hossein A.
    Seeger, Werner
    Schermuly, Ralph T.
    [J]. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 2019, 60 (03) : 346 - 356
  • [8] The Right Ventricle Under Pressure Cellular and Molecular Mechanisms of Right-Heart Failure in Pulmonary Hypertension
    Bogaard, Harm J.
    Abe, Kohtaro
    Noordegraaf, Anton Vonk
    Voelkel, Norbert F.
    [J]. CHEST, 2009, 135 (03) : 794 - 804
  • [9] Clinical symptoms of right ventricular failure in experimental chronic pressure load are associated with progressive diastolic dysfunction
    Borgdorff, Marinus A. J.
    Koop, Anne Marie C.
    Bloks, Vincent W.
    Dickinson, Michael G.
    Steendijk, Paul
    Sillje, Herman H. W.
    van Wiechen, Maarten P. H.
    Berger, Rolf M. F.
    Bartelds, Beatrijs
    [J]. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2015, 79 : 244 - 253
  • [10] Contribution of Impaired Parasympathetic Activity to Right Ventricular Dysfunction and Pulmonary Vascular Remodeling in Pulmonary Arterial Hypertension
    Bos, Denielli da Silva Goncalves
    Van Der Bruggen, Cathelijne E. E.
    Kurakula, Kondababu
    Sun, Xiao-Qing
    Casali, Karina R.
    Casali, Adenauer G.
    Rol, Nina
    Szulcek, Robert
    dos Remedios, Cris
    Guignabert, Christophe
    Tu, Ly
    Dorfmueller, Peter
    Humbert, Marc
    Wijnker, Paul J. M.
    Kuster, Diederik W. D.
    van der Velden, Jolanda
    Goumans, Marie-Jose
    Bogaard, Harm-Jan
    Vonk-Noordegraaf, Anton
    de Man, Frances S.
    Handoko, M. Louis
    [J]. CIRCULATION, 2018, 137 (09) : 910 - 924
123456789