Sequence analysis of segment A of a field virus isolate from an outbreak of infectious bursal disease in India

被引：0

作者：

Bais, MV ^{[1
]}

Kataria, RS ^{[1
]}

Tiwari, AK ^{[1
]}

Indervesh ^{[1
]}

Suryanarayana, VVS ^{[1
]}

Das, SK ^{[1
]}

机构：

[1] Indian Vet Res Inst, Natl Biotechnol Ctr, Izatnagar 243122, Uttar Pradesh, India

来源：

ACTA VIROLOGICA | 2003年 / 47卷 / 02期

关键词：

infectious bursal disease virus; nucleotide sequence; amino acid sequence; segment A;

D O I：

暂无

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Sequence analysis of genome segment A of an Indian Infectious bursal disease virus (IBDV) field isolate (KT1/99) revealed total 95 nucleotide substitutions, resulting in 17 amino acid changes. Of these, five amino acid changes, namely F60S, T137I, I374V, V519I and E682D were unique to the KT1/99 isolate. The amino acid change P222A and the proposed hot mutation spot 680Y, reported to be present in very virulent IBDV isolates were also found in KT1/99. This isolate had nucleotide divergence of 1.1% to 4.95% from the other reported serotype 1 IBDV isolates and 19.6% from serotype 2 strain OH in polyprotein gene sequence, while divergence at amino acid level was 0.6% to 2.9% and 11.4%, respectively. Based on both nucleotide and amino acid sequence analysis, KT1/99 was grouped phylogenetically with the reported Bangladesh isolate BD3/99 in one cluster along with other reported very virulent isolates in same lineage.

引用

页码：73 / 77

页数：5

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