Bevacizumab improves tumor infiltration of mature dendritic cells and effector T-cells in triple-negative breast cancer patients

被引：31

作者：

Boucher, Yves ^{[1
,2
]}

Kumar, Ashwin S. ^{[1
,2
,3
]}

Posada, Jessica M. ^{[1
,2
,4
]}

Gjini, Evisa ^{[5
,6
]}

Pfaff, Kathleen ^{[5
]}

Lipschitz, Mikel ^{[5
]}

Lako, Ana ^{[5
,6
]}

Duda, Dan G. ^{[1
,2
]}

Rodig, Scott J. ^{[4
,5
]}

Hodi, F. Stephen ^{[5
,7
]}

Jain, Rakesh K. ^{[1
,2
]}

机构：

[1] Massachusetts Gen Hosp, Dept Radiat Oncol, Edwin L Steele Labs, Boston, MA 02114 USA

[2] Harvard Med Sch, Boston, MA 02115 USA

[3] MIT, Harvard MIT Div Hlth Sci & Technol, Cambridge, MA 02139 USA

[4] Brigham & Womens Hosp, Dept Pathol, 75 Francis St, Boston, MA 02115 USA

[5] Dana Farber Canc Inst, Ctr Immunooncol, Boston, MA 02115 USA

[6] Bristol Myers Squibb, Cambridge, MA USA

[7] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA

来源：

NPJ PRECISION ONCOLOGY | 2021年 / 5卷 / 01期

关键词：

ENDOTHELIAL GROWTH-FACTOR; NORMALIZATION; CHEMOTHERAPY;

D O I：

10.1038/s41698-021-00197-w

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A single dose of bevacizumab reduced the density of angiopoietin-2-positive vessels while improving the infiltration of CD4+ T and CD8+ T cells, and mature dendritic cells in patients with primary triple-negative breast cancer. Our findings provide a rationale for including bevacizumab during neoadjuvant treatment to enhance the efficacy of immune checkpoint blockers in this disease.

引用

页数：6

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