Adiponectin: a versatile player of innate immunity

被引：178
作者：
Luo, Yan [1 ,2 ]
Liu, Meilian [1 ,2 ]
机构：
[1] Cent S Univ, Xiangya Hosp 2, Inst Metab & Endocrinol, Metab Syndrome Res Ctr, Changsha 410011, Hunan, Peoples R China
[2] Univ New Mexico, Dept Biochem & Mol Biol, Hlth Sci Ctr, Albuquerque, NM 87131 USA
来源：
JOURNAL OF MOLECULAR CELL BIOLOGY | 2016年 / 8卷 / 02期
基金：
美国国家卫生研究院;
关键词：
adiponectin; innate immunity; macrophage; innate-like lymphocyte; ACTIVATED PROTEIN-KINASE; DELTA-T-CELLS; INDUCED INSULIN-RESISTANCE; VISCERAL ADIPOSE-TISSUE; DIET-INDUCED OBESITY; INVARIANT NKT CELLS; RAT KUPFFER CELLS; KAPPA-B; BEIGE FAT; MACROPHAGE POLARIZATION;
D O I：
10.1093/jmcb/mjw012
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Adiponectin acts as a key regulator of the innate immune system and plays a major role in the progression of inflammation and metabolic disorders. Macrophages and monocytes are representative components of the innate immune system, and their proliferation, plasticity, and polarization are a key component of metabolic adaption. Innate-like lymphocytes such as group 2 innate lymphoid cells (ILC2s), natural killer T (NKT) cells, and gamma delta T (gamma delta T) cells are also members of the innate immune system and play important roles in the development of obesity and its related diseases. Adiponectin senses metabolic stress and modulates metabolic adaption by targeting the innate immune system under physiological and pathological conditions. Defining the mechanisms underlying the role of adiponectin in regulating innate immunity is crucial to adiponectin-based therapeutic intervention.
引用
收藏
页码：120 / 128
页数：9
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