Transplant Tourism Outcome: A Single Center Experience

被引:24
|
作者
Alghamdi, Saad A. [1 ]
Nabi, Zahid G. [1 ]
Alkhafaji, Dania M. [1 ]
Askandrani, Sumaya A. [1 ]
Abdelsalam, Mohamed S. [1 ]
Shukri, Mohamed M. [2 ]
Eldali, Abdelmoneim M. [2 ]
Adra, Chaker N. [3 ,4 ,5 ]
Alkurbi, Lutfi A. [1 ]
Albaqumi, Mamdouh N. [1 ,6 ]
机构
[1] King Faisal Specialist Hosp & Res Ctr, Nephrol Sect, Dept Med, Riyadh 11211, Saudi Arabia
[2] King Faisal Specialist Hosp & Res Ctr, Dept Biostat & Epidemiol, Riyadh 11211, Saudi Arabia
[3] King Faisal Specialist Hosp & Res Ctr, Stem Cell Therapy Program, Res Ctr, Riyadh 11211, Saudi Arabia
[4] Brigham & Womens Hosp, TRC, Boston, MA 02115 USA
[5] Harvard Univ, Sch Med, Childrens Hosp Boston, Cambridge, MA 02138 USA
[6] NYU, Med Ctr, Dept Med, Div Nephrol, New York, NY 10003 USA
关键词
Transplant tourism; Living unrelated kidney transplant; KIDNEY-TRANSPLANTATION; UNITED-STATES; ORGAN TRAFFICKING; OVERSEAS; DECLARATION;
D O I
10.1097/TP.0b013e3181e11763
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Background. Transplant tourism is the term used for patients who travel abroad for transplantation. Transplant tourism has always been surrounded with controversy regarding how these organs were obtained, the donor's care after transplantation, and the recipient outcome. Many authors have found that the outcome of the recipients in transplant tourism is inferior to those transplanted in their own countries. However, most these studies were small, with the latest one including only 33 patients. Here, we describe the outcome of 93 patients who were transplanted abroad compared with local transplantation. Material and Methods. All transplant patients who were followed up at our Nephrology Clinic from 1998 until 2008 were identified using our data base system. We selected patients transplanted from 2003 and forward because the computerized system for laboratory and electronic records began operation that year. Results. A total of 165 patients were identified (93 in the tourist group and 72 in the local one). Transplant tourists had a higher rate of acute rejection in the first year compared with local transplantation (27.9% vs. 9.9, P=0.005), higher mean creatinine at 6 months and 1 year (120 vs. 101 mu mol/L, P=0.0007, 113 vs. 98 mu mol/L, P=0.008). There was no statistical difference in graft or patient survival in 1 or 2 years after transplantation. However, transplant tourist had a higher rate of cytomegalovirus infection (15.1% vs. 5.6%, P=0.05) and hepatitis C seroconversion (7.5% vs. 0%, P=0.02). Conclusion. Transplant tourists had a more complex posttransplantation course with higher incidence of acute rejection and infectious complications.
引用
收藏
页码:184 / 188
页数:5
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