EMT in cervical cancer: Its role in tumour progression and response to therapy

被引：253
作者：
Qureshi, Rehana [1 ]
Arora, Himanshu [2 ]
Rizvi, M. A. [1 ]
机构：
[1] Jamia Millia Islamia, Dept Biosci, Genome Biol Lab, New Delhi 110025, India
[2] Univ Strasbourg, ESBS API Pole, CNRS, IREBS UMR7242, F-67412 Illkirch Graffenstaden, France
来源：
CANCER LETTERS | 2015年 / 356卷 / 02期
关键词：
Epithelial Mesenchymal Transition; Mesenchymal transition (EMT); Therapeutics; Oncogene; Tumour-suppressor; Cervical cancer; EPITHELIAL-MESENCHYMAL TRANSITION; ASTROCYTE-ELEVATED GENE-1; NF-KAPPA-B; GROWTH-FACTOR RECEPTOR; LYMPH-NODE METASTASIS; FUSED TOES HOMOLOG; CELL-MIGRATION; E-CADHERIN; DOWN-REGULATION; MIR-200; FAMILY;
D O I：
10.1016/j.canlet.2014.09.021
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The prognosis of cervical patients significantly decreases as the cancer metastasizes to other parts of the body. The epithelial to mesenchymal transition (EMT) plays an important role in cervical cancer progression and metastasis. Recurrence is the primary cause of the increased number of deaths due to cervical cancer. Oncogenes, such as AEG1, Sam-68, FTS and miR-361-5p, induce EMT in cervical cancer. Tumour suppressors, such as LMX-1, SFRP1, klotho, and miR-155, suppress EMT in cervical cancer. Factors such as hypoxia, the radiation dose, cytokines, proteins, transcription factors, and signalling pathways also play an important role in the induction, progression and maintenance of EMT in cervical cancer. Overall, this review describes a wide range of factors with potential roles in EMT that have been identified to date, and this information could be important for the development of new and more effective therapeutics that ameliorate the negative impact of cervical pathogenesis via EMT. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：321 / 331
页数：11
相关论文
共 167 条
  • [1] Epithelial-mesenchymal transitions: the importance of changing cell state in development and disease
    Acloque, Herve
    Adams, Meghan S.
    Fishwick, Katherine
    Bronner-Fraser, Marianne
    Angela Nieto, M.
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 2009, 119 (06) : 1438 - 1449
  • [2] Curcumin (diferuloylmethane) down-regulates expression of cell proliferation and antiapoptotic and metastatic gene products through suppression of IκBα kinase and Akt activation
    Aggarwal, S
    Ichikawa, H
    Takada, Y
    Sandur, SK
    Shishodia, S
    Aggarwal, BB
    [J]. MOLECULAR PHARMACOLOGY, 2006, 69 (01) : 195 - 206
  • [3] HPV typing and its relation with apoptosis in cervical carcinoma from Indian population
    Alam, M. Shabbir
    Ali, Asgar
    Mehdi, Syed Jafar
    Alyasiri, Nisreen Sherif
    Kazim, Zakia
    Batra, Swaraj
    Mandal, A. K.
    Rizvi, M. Moshahid Alam
    [J]. TUMOR BIOLOGY, 2012, 33 (01) : 17 - 22
  • [4] Cancer stem cells: In the line of fire
    Alison, Malcolm R.
    Lin, Wey-Ran
    Lim, Susan M. L.
    Nicholson, Linda J.
    [J]. CANCER TREATMENT REVIEWS, 2012, 38 (06) : 589 - 598
  • [5] MicroRNAs: Target Recognition and Regulatory Functions
    Bartel, David P.
    [J]. CELL, 2009, 136 (02) : 215 - 233
  • [6] Cadherins and catenins: Role in signal transduction and tumor progression
    Behrens, J
    [J]. CANCER AND METASTASIS REVIEWS, 1999, 18 (01) : 15 - 30
  • [7] Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs): Positive and negative regulators in tumor cell adhesion
    Bourboulia, Dimitra
    Stetler-Stevenson, William G.
    [J]. SEMINARS IN CANCER BIOLOGY, 2010, 20 (03) : 161 - 168
  • [8] Molecular aspects of resistance to antitumor platinum drugs
    Brabec, V
    Kasparkova, J
    [J]. DRUG RESISTANCE UPDATES, 2002, 5 (3-4) : 147 - 161
  • [9] A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells
    Burk, Ulrike
    Schubert, Joerg
    Wellner, Ulrich
    Schmalhofer, Otto
    Vincan, Elizabeth
    Spaderna, Simone
    Brabletz, Thomas
    [J]. EMBO REPORTS, 2008, 9 (06) : 582 - 589
  • [10] The RNA-binding protein Sam68 contributes to proliferation and survival of human prostate cancer cells
    Busa, R.
    Paronetto, M. P.
    Farini, D.
    Pierantozzi, E.
    Botti, F.
    Angelini, D. F.
    Attisani, F.
    Vespasiani, G.
    Sette, C.
    [J]. ONCOGENE, 2007, 26 (30) : 4372 - 4382
12345678910