Pediatric tizanidine toxicity reversed with naloxone: a case report

被引：1

作者：

Bader, Doaa ^{[1
]}

Adam, Ahmed ^{[1
]}

Shaban, Mohamed ^{[1
]}

Alyahya, Bader ^{[2
]}

机构：

[1] Royal Commiss Med Ctr, Yanbu 46451, Saudi Arabia

[2] King Saud Univ, King Saud Univ Med City, Emergency Med Dept, Box 2925, Riyadh 11461, Saudi Arabia

来源：

INTERNATIONAL JOURNAL OF EMERGENCY MEDICINE | 2021年 / 14卷 / 01期

关键词：

Tizanidine; Naloxone; Toxicology; Pediatric; CLONIDINE; SPASTICITY; OVERDOSE;

D O I：

10.1186/s12245-021-00397-y

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Background Tizanidine, an alpha-2 adrenoceptor agonist, is widely prescribed for the management of spasticity in adults. Case reports on pediatric tizanidine overdose are limited. Here, we report a case of pediatric tizanidine toxicity that was reversed with naloxone. Case presentation A 3-year-old male presented to the emergency department with lethargy, bradycardia, and bradypnea after accidental ingestion of multiple tizanidine tablets. Improvements in the level of consciousness and respiratory and heart rates were observed after two intravenous administrations of naloxone at a dose of 0.05 and 0.1 mg/kg, respectively. Conclusions This case report provides further evidence regarding the use of naloxone as a viable antidote for centrally acting alpha-2 receptor agonists and presents additional epidemiologic data on childhood tizanidine poisoning.

引用

页数：3

共 16 条

[1]

Ahmad SA, 2015, AM J THER, V22, pE14, DOI 10.1097/MJT.0b013e318293b0e8

[2] FAILURE OF NALOXONE TO REVERSE CLONIDINE TOXIC EFFECT [J].