Myelodysplastic Syndromes with Bone Marrow Fibrosis : An Update

被引：24

作者：

Jain, Akriti G. ^{[1
]}

Zhang, Ling ^{[2
]}

Bennett, John M. ^{[3
]}

Komrokji, Rami ^{[4
]}

机构：

[1] H Lee Moffitt Canc Ctr & Res Inst, Dept Hematol & Oncol, 12902 USF Magnolia Dr, Tampa, FL 33612 USA

[2] H Lee Moffitt Canc Ctr & Res Inst, Dept Hematopathol & Lab Med, Tampa, FL USA

[3] Univ Rochester, Hematopathol Div, Dept Pathol, Med Ctr, Rochester, NY USA

[4] H Lee Moffitt Canc Ctr & Res Inst, Dept Malignant Hematol, Tampa, FL USA

来源：

ANNALS OF LABORATORY MEDICINE | 2022年 / 42卷 / 03期

关键词：

Myelodysplastic syndrome; Bone marrow fibrosis; International prognostic scoring system; Allogeneic stem cell transplantation; Key Words; WORLD-HEALTH-ORGANIZATION; EUROPEAN CONSENSUS; MYELOID NEOPLASMS; ACUTE-LEUKEMIA; MYELOFIBROSIS; CLASSIFICATION; REVISION;

D O I：

10.3343/alm.2022.42.3.299

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Myelodysplastic syndrome (MDS) is a diverse hematological malignancy with a wide spectrum of presentations and implications. Treatment strategies for patients with MDS heavily rely on prognostic scoring systems, such as the revised international prognostic scoring system (IPSS-R). Bone marrow fibrosis (BMF) has been identified as an independent risk factor for poor survival in patients with MDS, irrespective of the IPSS-R risk category. However, BMF is not widely included in scoring systems and is not always considered by clinicians when making treatment decisions for patients. In this review, we discuss the available literature about the presentation and prognosis of patients with MDS and concurrent BMF. The prognostic impact of BMF should be factored in when deciding on transplant candidacy, especially for intermediate-risk patients.

引用

页码：299 / 305

页数：7

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