Impact of neurodegenerative diseases on human adult hippocampal neurogenesis

被引：190

作者：

Terreros-Roncal, J. ^{[1
,2
,3
]}

Moreno-Jimenez, E. P. ^{[1
,2
,3
]}

Flor-Garcia, M. ^{[1
,2
,3
]}

Rodriguez-Moreno, C. B. ^{[1
,3
]}

Trinchero, M. F. ^{[4
]}

Cafini, F. ^{[5
]}

Rabano, A. ^{[6
]}

Llorens-Martin, M. ^{[1
,3
]}

机构：

[1] Univ Autonoma Madrid UAM, Ctr Biol Mol Severo Ochoa CBMSO, Spanish Res Council CSIC, Dept Mol Neuropathol, Madrid, Spain

[2] Univ Autonoma Madrid, Fac Sci, Dept Mol Biol, Madrid, Spain

[3] Ctr Networked Biomed Res Neurodegenerat Dis CIBER, Madrid, Spain

[4] Leloir Inst IIBBA CONICET, Lab Neuronal Plastic, Buenos Aires, DF, Argentina

[5] Univ Europea Madrid, Fac Biomed & Hlth Sci, Madrid, Spain

[6] CIEN Fdn, Neuropathol Dept, Madrid, Spain

来源：

SCIENCE | 2021年 / 374卷 / 6571期

基金：

欧洲研究理事会;

关键词：

CELL-PROLIFERATION; SUFFICIENT; NEURONS; NICHE;

D O I：

10.1126/science.abl5163

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Disrupted hippocampal performance underlies psychiatric comorbidities and cognitive impairments in patients with neurodegenerative disorders. To understand the contribution of adult hippocampal neurogenesis (AHN) to amyotrophic lateral sclerosis, Huntington's disease, Parkinson's disease, dementia with Lewy bodies, and frontotemporal dementia, we studied postmortem human samples. We found that adult-born dentate granule cells showed abnormal morphological development and changes in the expression of differentiation markers. The ratio of quiescent to proliferating hippocampal neural stem cells shifted, and the homeostasis of the neurogenic niche was altered. Aging and neurodegenerative diseases reduced the phagocytic capacity of microglia, triggered astrogliosis, and altered the microvasculature of the dentate gyrus. Thus, enhanced vulnerability of AHN to neurodegeneration might underlie hippocampal dysfunction during physiological and pathological aging in humans.

引用

页码：1106 / +

页数：62

共 35 条

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