Diffractometric Biochemical Sensing with Smart Hydrogels

被引：8
作者：
Chang, Chun-Li [1 ,2 ]
Ding, Zhenwen [2 ,3 ]
Patchigolla, Venkata N. L. R. [1 ,2 ]
Ziaie, Babak [2 ,4 ]
Savran, Cagri A. [1 ,2 ]
机构：
[1] Purdue Univ, Sch Mech Engn, W Lafayette, IN 47907 USA
[2] Purdue Univ, Birck Nanotechnol Ctr, W Lafayette, IN 47907 USA
[3] Purdue Univ, Dept Phys, W Lafayette, IN 47907 USA
[4] Purdue Univ, Sch Elect & Comp Engn, W Lafayette, IN 47907 USA
来源：
2010 IEEE SENSORS | 2010年
关键词：
SENSOR; PH; CANTILEVER;
D O I：
10.1109/ICSENS.2010.5690402
中图分类号：
TM [电工技术]; TN [电子技术、通信技术];
学科分类号：
0808 ; 0809 ;
摘要：
We report reflective diffraction gratings made from smart hydrogels for ultrasensitive biochemical detection. As an example for a biochemically responsive hydrogel, we chose a pH-sensitive hydrogel to construct diffraction gratings that swell or shrink due to changes in pH. Interferometric analysis of the grating enabled detection of the hydrogel's swelling/shrinking with nanoscale precision with a resolution of 6x10(-4) pH units. The developed system is remarkably simple both to fabricate and operate. Moreover, the concept of the hydrogel grating is generic and can be widely applied to hydrogels responsive to other stimuli.
引用
收藏
页码：1617 / 1621
页数：5
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共 22 条
  • [1] Micromechanical cantilever as an ultrasensitive pH microsensor
    Bashir, R
    Hilt, JZ
    Elibol, O
    Gupta, A
    Peppas, NA
    [J]. APPLIED PHYSICS LETTERS, 2002, 81 (16) : 3091 - 3093
  • [2] In situ assembled diffraction grating for biomolecular detection
    Chang, Chun-Li
    Acharya, Ghanashyam
    Savran, Cagri A.
    [J]. APPLIED PHYSICS LETTERS, 2007, 90 (23)
  • [3] Microgels: Old materials with new applications
    Das, Mallika
    Zhang, Hong
    Kumacheva, Eugenia
    [J]. ANNUAL REVIEW OF MATERIALS RESEARCH, 2006, 36 : 117 - 142
  • [4] A miniaturized carbon dioxide gas sensor based on sensing of pH-sensitive hydrogel swelling with a pressure sensor
    Herber, S
    Bomer, J
    Olthuis, W
    Bergveld, P
    van den Berg, A
    [J]. BIOMEDICAL MICRODEVICES, 2005, 7 (03) : 197 - 204
  • [5] Ultrasensitive biomems sensors based on microcantilevers patterned with environmentally responsive hydrogels
    Hilt, JZ
    Gupta, AK
    Bashir, R
    Peppas, NA
    [J]. BIOMEDICAL MICRODEVICES, 2003, 5 (03) : 177 - 184
  • [6] Review on state-of-the-art in polymer based pH sensors
    Korostynska, Olga
    Arshak, Khalil
    Gill, Edric
    Arshak, Arousian
    [J]. SENSORS, 2007, 7 (12) : 3027 - 3042
  • [7] Measurement of pH and dissolved oxygen within cell culture media using a hydrogel microarray sensor
    Lee, Seungjoon
    They, Bennett L.
    Cote, Gerard L.
    Pishko, Michael V.
    [J]. SENSORS AND ACTUATORS B-CHEMICAL, 2008, 128 (02) : 388 - 398
  • [8] Integration of hydrogels with hard and soft microstructures
    Lei, Ming
    Ziaie, Babak
    Nuxoll, Eric
    Ivan, Kristof
    Noszticzius, Zoltan
    Siegel, Ronald A.
    [J]. JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, 2007, 7 (03) : 780 - 789
  • [9] Differential selection pressure exerted on HIV by CTL targeting identical epitopes but restricted by distinct HLA alleles from the same HLA supertype. (vol 177, pg 4699, 2006)
    Leslie, A.
    Price, D. A.
    Mkhize, P.
    Bishop, K.
    Rathod, A.
    Day, C.
    Crawford, H.
    Honeyborne, I.
    Asher, T. E.
    Luzzi, G.
    Edwards, A.
    Rosseau, C. M.
    Mullins, J. I.
    Tudor-Williams, G.
    Novelli, V.
    Brander, C.
    Douek, D. C.
    Kiepiela, P.
    Walker, B. D.
    Goulder, P. J. R.
    [J]. JOURNAL OF IMMUNOLOGY, 2006, 177 (12) : 8878 - 8878
  • [10] Microvolume field-effect pH sensor for the scanning probe microscope
    Manalis, SR
    Cooper, EB
    Indermuhle, PF
    Kernen, P
    Wagner, P
    Hafeman, DG
    Minne, SC
    Quate, CF
    [J]. APPLIED PHYSICS LETTERS, 2000, 76 (08) : 1072 - 1074
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