D-Serine alleviates retrograde amnesia of a visual discrimination task in rats with a lesion of the perirhinal cortex

被引：12

作者：

Andersen, JM ^{[1
]}

Fonnum, F ^{[1
]}

Myhrer, T ^{[1
]}

机构：

[1] Norwegian Def Res Estab, Div Protect & Mat, N-2027 Kjeller, Norway

来源：

BRAIN RESEARCH | 2003年 / 979卷 / 1-2期

关键词：

D-serine; perirhinal cortex; memory; Alzheimer's disease;

D O I：

10.1016/S0006-8993(03)02894-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

D-Serine has been suggested to be a potent endogenous glycine-site agonist on the N-methyl-D-aspartate receptor, thereby having a potential role in the process of learning and memory. In rats, perirhinal cortex (PC) constitutes a particularly important structure for mnemonic processing, and damage to this area induces both anterograde and retrograde amnesia. In the present work, we show that intraperitoneal administration of 1000 mg/kg D-serine immediately after bilateral lesion of PC produced complete restoration of retrograde memory in rats, measured by a visual brightness discrimination task, while a higher dose (3000 mg/kg) did not show any reliable effect. Uptake of the drug into the brain was confirmed using high performance liquid chromatography (HPLC). (C) 2003 Elsevier B.V. All rights reserved.

引用

页码：240 / 244

页数：5

共 36 条

[31]

Schell MJ, 1997, J NEUROSCI, V17, P1604

[32] D-CYCLOSERINE, A MODULATOR OF THE N-METHYL-D-ASPARTATE RECEPTOR, IMPROVES SPATIAL-LEARNING IN RATS TREATED WITH MUSCARINIC ANTAGONIST [J].

SIRVIO, J ;

EKONSALO, T ;

RIEKKINEN, P ;

LAHTINEN, H ;

RIEKKINEN, P .

NEUROSCIENCE LETTERS, 1992, 146 (02) :215-218

[33] Genetic enhancement of learning and memory in mice [J].

Tang, YP ;

Shimizu, E ;

Dube, GR ;

Rampon, C ;

Kerchner, GA ;

Zhuo, M ;

Liu, GS ;

Tsien, JZ .

NATURE, 1999, 401 (6748) :63-69

[34]

TANII Y, 1994, J PHARMACOL EXP THER, V269, P1040

[35] Temporally graded retrograde amnesia following separate and combined lesions of the perirhinal cortex and fornix in the rat [J].

Wiig, KA ;

Cooper, LN ;

Bear, MF .

LEARNING & MEMORY, 1996, 3 (04) :313-325

[36] INVIVO MODULATION OF THE N-METHYL-D-ASPARTATE RECEPTOR COMPLEX BY D-SERINE - POTENTIATION OF ONGOING NEURONAL-ACTIVITY AS EVIDENCED BY INCREASED CEREBELLAR CYCLIC-GMP [J].

WOOD, PL ;

EMMETT, MR ;

RAO, TS ;

MICK, S ;

CLER, J ;

IYENGAR, S .

JOURNAL OF NEUROCHEMISTRY, 1989, 53 (03) :979-981

← 1 2 3 4 →