Can Plateletcrit be a Marker for Recurrent Pregnancy Loss?

被引：30

作者：

Aynioglu, Oner ^{[1
]}

Isik, Hatice ^{[1
]}

Sahbaz, Ahmet ^{[1
]}

Harma, Mehmet I. ^{[1
]}

Isik, Metin ^{[2
]}

Kokturk, Furuzan ^{[3
]}

机构：

[1] Bulent Ecevit Univ, Dept Gynecol & Obstet, Fac Med, Zonguldak, Turkey

[2] Bulent Ecevit Univ, Dept Romatol, Fac Med, Zonguldak, Turkey

[3] Bulent Ecevit Univ, Dept Biostat, Fac Med, Zonguldak, Turkey

来源：

CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS | 2016年 / 22卷 / 05期

关键词：

clinical thrombophilia; recurrent abortion; hemostasis; LYMPHOCYTE RATIO; PROTEIN-C; WOMEN; INDEXES; THROMBOPHILIA; MISCARRIAGE; THROMBOCYTOSIS; COAGULATION; NEUTROPHIL; ANTIBODIES;

D O I：

10.1177/1076029614565882

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Aim: To determine the utility of platelet (PLT) indices for the prediction of recurrent pregnancy loss (RPL). Methods: In all, 208 patients who experienced 2 or more first trimester spontaneous abortions and 95 controls who had no abortions were studied. The hematological markers, including plateletcrit (PCT) and neutrophil (Neu) to lymphocyte (Lym) ratio (NLR), were measured. Thrombophilia genetic tests for factor V Leiden mutation, prothrombin G202I0A mutation, and methylenetetrahydrofolate reductase C677 T and A1298C mutations were performed. Results: The PLT count, PCT, white blood cell count, red cell distribution width (RDW), Lym and Neu count, and NLR were significantly higher in patients with RPL than in controls. The RDW, PLT, and PCT values were higher in the low-risk group, whereas mean PLT volume values were lower than the high-risk group values. Conclusion: Plateletcrit is a low-cost, widely available marker for prediction of RPL in patients with a history of at least 1 abortus.

引用

页码：447 / 452

页数：6

共 30 条

[1] Relationship between platelet indices and spontaneous echo contrast in patients with mitral stenosis
Akpek, Mahmut
Kaya, Mehmet G.
Yarlioglues, Mikail
Dogdu, Orhan
Ardic, Idris
Sahin, Omer
Elcik, Deniz
Ozdogru, Ibrahim
Topsakal, Ramazan
Oguzhan, Abdurrahman
Ergin, Ali
Kalay, Nihat
[J]. EUROPEAN JOURNAL OF ECHOCARDIOGRAPHY, 2011, 12 (11): : 865 - 870
[2] Akpinar I, 2014, HERZ, V39, P142, DOI 10.1007/s00059-013-3798-y
[3] American College of Obstetricians and Gynecologists, 2001, Obstet Gynecol, V98, P709
[4] American College of Obstetricians and Gynecologists Women's Health Care Physicians, 2013, Obstet Gynecol, V122, P706, DOI 10.1097/01.AOG.0000433981.36184.4e
[5] Recurrent miscarriage syndrome and infertility due to blood coagulation protein/platelet defects: A review and update
Bick, RL
Hoppensteadt, D
[J]. CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS, 2005, 11 (01) : 1 - 13
[6] Thrombophilia-associated gene mutations in women with pregnancies complicated by fetal neural tube defects
Ceyhan, Seyit Temel
Beyan, Cengiz
Bahce, Muhterem
Baser, Iskender
Kaptan, Kursat
Ifran, Ahmet
Egin, Yonca
Akar, Nejat
[J]. INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS, 2008, 101 (02) : 188 - 189
[7] Evidence-based investigations and treatments of recurrent pregnancy loss
Christiansen, OB
Andersen, AMN
Bosch, E
Daya, S
Delves, PJ
Hviid, TV
Kutteh, WH
Laird, SM
Li, TC
van der Ven, K
[J]. FERTILITY AND STERILITY, 2005, 83 (04) : 821 - 839
[8] Clark DA, 1998, J IMMUNOL, V160, P545
[9] Clark P, 1998, THROMB HAEMOSTASIS, V79, P1166
[10] Inherited Thrombophilias and Adverse Pregnancy Outcomes A Review of Screening Patterns and Recommendations
Davenport, William B.
Kutteh, William H.
[J]. OBSTETRICS AND GYNECOLOGY CLINICS OF NORTH AMERICA, 2014, 41 (01) : 133 - +

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