Nickel(ii)-catalyzed C-C, N-C cascade coupling of ketonitriles into substituted pyrroles and pyridines

被引：30

作者：

Zhen, Qianqian ^{[1
]}

Li, Renhao ^{[2
]}

Qi, Linjun ^{[1
]}

Hu, Kun ^{[1
]}

Yao, Xinrong ^{[1
]}

Shao, Yinlin ^{[1
]}

Chen, Jiuxi ^{[1
]}

机构：

[1] Wenzhou Univ, Coll Chem & Mat Engn, Wenzhou 325035, Peoples R China

[2] Wenzhou Med Univ, Sch Pharmaceut Sci, Wenzhou 325035, Peoples R China

来源：

ORGANIC CHEMISTRY FRONTIERS | 2020年 / 7卷 / 02期

基金：

中国国家自然科学基金;

关键词：

CATALYZED TANDEM ADDITION/CYCLIZATION; ALIPHATIC NITRILES SYNTHESIS; ALKYL ARYL KETONES; ONE-POT SYNTHESIS; ARYLBORONIC ACIDS; DIARYLIODONIUM SALTS; EFFICIENT SYNTHESIS; DIRECT ADDITION; PALLADIUM; CONSTRUCTION;

D O I：

10.1039/c9qo01259a

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We have demonstrated the first ever example of nickel complexes as effective catalysts to promote the C-C, N-C cascade coupling of ketonitriles with arylboronic acids, affording potentially biologically active 3-carboxylate-2,5-diaryl-pyrroles as well as 2,5-diarylpyrroles and 2,6-diarylpyridines. This protocol features a broad scope of substrates and excellent functional group tolerance, thus representing a highly versatile and atom-economical alternative to novel methods for the synthesis of various unsymmetrical diarylpyrroles and diarylpyridines under manageable conditions.

引用

页码：286 / 291

页数：6

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