Recent research progress on microbial L-asparaginases

被引：63
|
作者：
Zuo, Shaohua [1 ]
Zhang, Tao [1 ]
Jiang, Bo [1 ,2 ]
Mu, Wanmeng [1 ,2 ]
机构：
[1] Jiangnan Univ, State Key Lab Food Sci & Technol, Minist Educ, Key Lab Carbohydrate Chem & Biotechnol, Wuxi 214122, Jiangsu, Peoples R China
[2] Jiangnan Univ, Synerget Innovat Ctr Food Safety & Nutr, Wuxi 214122, Peoples R China
来源：
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY | 2015年 / 99卷 / 03期
关键词：
L-Asparaginase; Acute lymphoblastic leukemia; Acrylamide; Production; Modification; Immobilization; CAROTOVORUM MTCC 1428; PROMISING CHEMOTHERAPEUTIC-AGENT; RESPONSE-SURFACE METHODOLOGY; BACILLUS-ARYABHATTAI ITBHU02; EXTRACELLULAR L-ASPARAGINASE; INTRACELLULAR L-ASPARAGINASE; ACUTE LYMPHOBLASTIC-LEUKEMIA; THERMOSTABLE L-ASPARAGINASE; SOLID-STATE FERMENTATION; ESCHERICHIA-COLI K-12;
D O I：
10.1007/s00253-014-6271-9
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
L-Asparaginases (EC 3.5.1.1) are enzymes that catalyze the hydrolysis of L-asparagine to L-aspartic acid and found in a variety of organisms from microorganisms to mammals. However, they are mainly expressed and produced by microorganisms. Microbial L-asparaginases have received sustained attention due to their irreplaceable role in the therapy of acute lymphoblastic leukemia and for their inhibition of acrylamide formation during food processing. In this article, we review the application of microbial L-asparaginases in medical treatments and acrylamide mitigation. In addition, we describe in detail recent advances in the existing sources, purification, production, properties, molecular modification, and immobilization of L-asparaginase.
引用
收藏
页码：1069 / 1079
页数：11
相关论文
共 50 条
  • [1] Recent research progress on microbial l-asparaginases
    Shaohua Zuo
    Tao Zhang
    Bo Jiang
    Wanmeng Mu
    Applied Microbiology and Biotechnology, 2015, 99 : 1069 - 1079
  • [2] A critical review on properties and applications of microbial L-asparaginases
    Krishnapura, Prajna Rao
    Belur, Prasanna D.
    Subramanya, Sandeep
    CRITICAL REVIEWS IN MICROBIOLOGY, 2016, 42 (05) : 720 - 737
  • [3] Insights into the Microbial L-Asparaginases: From Production to Practical Applications
    Sharma, Deepankar
    Singh, Kushagri
    Singh, Kavita
    Mishra, Abha
    CURRENT PROTEIN & PEPTIDE SCIENCE, 2019, 20 (05) : 452 - 464
  • [4] ANTIBODIES TO BACTERIAL L-ASPARAGINASES
    ELHAG, KM
    BETTELHEIM, KA
    HUBER, TJ
    NEW ZEALAND MEDICAL JOURNAL, 1977, 86 (596) : 280 - 281
  • [5] L-Asparaginases of Extremophilic Microorganisms in Biomedicine
    M. V. Dumina
    M. A. Eldarov
    D. D. Zdanov
    N. N. Sokolov
    Biochemistry (Moscow), Supplement Series B: Biomedical Chemistry, 2020, 14 : 277 - 296
  • [6] Desirable L-asparaginases for treating cancer and current research trends
    Tsegaye, Kindu
    Tsehai, Berhanu Andualem
    Getie, Birhan
    FRONTIERS IN MICROBIOLOGY, 2024, 15
  • [7] Looking into the thermostable archaeal L-asparaginases
    Sania, Ayesha
    Sajed, Muhammad
    Rashid, Naeem
    BIOLOGIA, 2024, : 3637 - 3648
  • [8] L-Asparaginases of Extremophilic Microorganisms in Biomedicine
    Dumina, M., V
    Eldarov, M. A.
    Zdanov, D. D.
    Sokolov, N. N.
    BIOCHEMISTRY MOSCOW-SUPPLEMENT SERIES B-BIOMEDICAL CHEMISTRY, 2020, 14 (04) : 277 - 296
  • [9] L-Asparaginases and Their Potential in Biotechnology and Medicine
    Pejskova, Lucie
    Louzecka, Karolina
    Podzimek, Tomas
    Benesova, Eva
    CHEMICKE LISTY, 2023, 117 (08): : 508 - 515
  • [10] IMMUNOLOGICAL RELATIONSHIPS OF BACTERIAL L-ASPARAGINASES
    BASCOMB, S
    BETTELHEIM, KA
    JOURNAL OF GENERAL MICROBIOLOGY, 1976, 92 (JAN): : 175 - 182
12345