Borax: An Ecofriendly and Efficient Catalyst for One-Pot Synthesis of 3,4-Dihydropyrimidine-2(1H)-ones under Solvent-Free Conditions

被引：10

作者：

Nath, Jayashree ^{[2
]}

Chaudhuri, Mihir K. ^{[1
,3
]}

机构：

[1] Indian Inst Technol Guwahati, Dept Chem, Gauhati 781039, India

[2] Indian Inst Technol Guwahati, Ctr Environm, Gauhati 781039, India

[3] Tezpur Univ, Tezpur, India

来源：

SYNTHETIC COMMUNICATIONS | 2010年 / 40卷 / 20期

关键词：

Biginelli reaction; borax; 3,4-dihydropyrimidin-2(1H)-ones; solvent free; BIGINELLI REACTION; REUSABLE CATALYST; PARALLEL SYNTHESIS; 3,4-DIHYDROPYRIMIDIN-2(1H)-ONES; DIHYDROPYRIMIDINONES; CHLORIDE;

D O I：

10.1080/00397910903341163

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Borax in the presence of a very small amount of 5M sulfuric acid efficiently catalyses the three-component condensation of an aldehyde, beta-ketoester, and urea or thiourea to afford the corresponding 3,4-dihydropyrimidin-2(1H)-ones or 3,4-dihydropyrimidin-2(1H)-thiones in good to excellent yields under solvent-free conditions at 80 degrees C. Compared with the classical Biginelli reaction conditions, this new method has the advantage of excellent yield, short reaction time (1-2h), easy workup, and no use of volatile organic solvent.

引用

页码：2976 / 2982

页数：7

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