Gold finger formation studied by high-resolution mass spectrometry and in silico methods

被引：32
|
作者：
Laskay, U. A. [1 ]
Garino, C. [2 ,3 ]
Tsybin, Y. O. [1 ]
Salassa, L. [4 ,5 ,6 ]
Casini, A. [7 ]
机构：
[1] Ecole Polytech Fed Lausanne, Biomol Mass Spectrometry Lab, CH-1015 Lausanne, Switzerland
[2] Univ Turin, Dept Chem, I-10125 Turin, Italy
[3] Univ Turin, NIS Ctr Excellence, I-10125 Turin, Italy
[4] CIC biomaGUNE, Donostia San Sebastia 20009, Spain
[5] Euskal Herriko Unibertsitatea, Kim Fak, Donostia San Sebastian, Euskadi, Spain
[6] Donostia Int Phys Ctr, Donostia San Sebastian, Euskadi, Spain
[7] Univ Groningen, Res Inst Pharm, Dept Pharmacokinet Toxicol & Targeting, NL-9713 AV Groningen, Netherlands
来源：
CHEMICAL COMMUNICATIONS | 2015年 / 51卷 / 09期
关键词：
ZINC-FINGER; FORCE-FIELD; PROTEINS; INHIBITION;
D O I：
10.1039/c4cc07490d
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
High-resolution mass spectrometry and quantum mechanics/molecular mechanics studies were employed for characterizing the formation of two gold finger (GF) domains from the reaction of zinc fingers (ZF) with gold complexes. The influence of both the gold oxidation state and the ZF coordination sphere in GF formation provided useful insights into the possible design of new gold complexes targeting specific ZF motifs.
引用
收藏
页码：1612 / 1615
页数：4
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