Studies on cytotoxic constituents from the skin of the toad Bufo bufo gargarizans

被引：26

作者：

Zhao, Hu-Yi ^{[1
]}

Wu, Fu-Kai ^{[2
]}

Qiu, Ying-Kun ^{[1
]}

Wu, Zhen ^{[1
]}

Jiang, Yong-Tao ^{[3
]}

Chen, Ji-Yong ^{[3
]}

机构：

[1] Xiamen Univ, Coll Med, Xiamen 361005, Peoples R China

[2] Xiamen Inst Drug Control, Xiamen 361012, Peoples R China

[3] Luye Pharmaceut Co Ltd, Yantai 264003, Peoples R China

来源：

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2010年 / 12卷 / 09期

关键词：

Bufo bufo gargarizans; toad skin; cinobufotalin 3-nonanedioylarginine ester; bufotalin 3-pimeloylarginine ester; cytotoxicity; BUFADIENOLIDES; STEROIDS; ASSIGNMENT;

D O I：

10.1080/10286020.2010.505187

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

To study the chemical composition of the skin of Bufo bufo gargarizans, many kinds of chromatography methods were used in the isolation procedures, while the structures of isolated compounds were determined on the basis of their NMR and MS spectral analysis. As a result, two new compounds were isolated from its ethanolic extract and characterized as cinobufotalin 3-nonanedioylarginine ester (8) and bufotalin 3-pimeloylarginine ester (14). Furthermore, 13 known compounds were obtained. Isolated bufadienolides showed significant inhibition effect against SMMC-7721 cell lines in vitro.

引用

页码：793 / 800

页数：8

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