Salvage Carbon-ion Radiotherapy for Isolated Lymph Node Recurrence Following Curative Resection of Esophageal Cancer

被引：14

作者：

Isozaki, Yuka ^{[1
]}

Yasuda, Shigeo ^{[1
]}

Akutsu, Yasunori ^{[2
]}

Shimada, Hideaki ^{[3
]}

Okazumi, Shinichi ^{[4
]}

Nabeya, Yoshihiro ^{[5
]}

Hoshino, Isamu ^{[5
]}

Murakami, Kentaro ^{[2
]}

Ebner, Daniel K. ^{[1
,6
]}

Tsuji, Hiroshi ^{[1
]}

Kamada, Tadashi ^{[1
]}

Yamada, Shigeru ^{[1
]}

Matsubara, Hisahiro ^{[2
]}

机构：

[1] Natl Inst Quantum & Radiol Sci & Technol, Hosp Natl Inst Radiol Sci, Chiba, Japan

[2] Chiba Univ, Grad Sch Med, Frontier Surg Dept, Chiba, Japan

[3] Toho Univ, Dept Gastroenterol Surg & Clin Oncol, Grad Sch Med, Tokyo, Japan

[4] Toho Univ, Dept Surg, Sakura Med Ctr, Chiba, Japan

[5] Chiba Canc Ctr, Div Gastroenterol Surg, Chiba, Japan

[6] Brown Univ, Alpert Med Sch, Providence, RI 02912 USA

来源：

ANTICANCER RESEARCH | 2018年 / 38卷 / 11期

关键词：

Esophageal cancer; lymph node recurrence; carbon-ion radiotherapy; SQUAMOUS-CELL CARCINOMA; EXTENDED RADICAL ESOPHAGECTOMY; RADIATION-THERAPY; PATTERN; CRITERIA; UPDATE;

D O I：

10.21873/anticanres.13007

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Aim: Evaluation of the therapeutic efficacy of carbon-ion radiation therapy for isolated lymph node recurrence following curative resection of esophageal cancer. Materials and Methods: Ten cases with lymph node recurrence after esophageal cancer surgery were treated with carbon-ion radiation therapy. A total of 48.0 Gy [relative biologic effectiveness (RBE)] was delivered over 3 weeks with a daily dose of 4.0 Gy (RBE). Results: The median follow-up duration was 27.1 months (range=3-92.0 months) after carbon-ion radiation therapy. The local control rates at 2, 3 and 5 years were 92.4%. The overall survival rates at 2, 3 and 5 years were 70.0%, 58.3% and 21.9%. The median survival period was 45.3 months after carbon-ion radiation therapy. There were no toxicities of grade 3 or higher. Conclusion: Carbon-ion radiation therapy may be a safe and effective treatment option for isolated lymph node recurrence after radical surgery for esophageal cancer.

引用

页码：6453 / 6458

页数：6

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