Dengue-associated Hemophagocytic Lymphohistiocytosis: A Rare Complication of a Common Infection in Singapore

被引:0
作者
Kam, Kai-qian [1 ]
Soh, Shui Yen [2 ]
Bhattacharyya, Rajat [2 ]
机构
[1] KK Womens & Childrens Hosp, Dept Paediat, Singapore, Singapore
[2] KK Womens & Childrens Hosp, Dept Paediat Subspecialties, Haematol Oncol Serv, Singapore, Singapore
关键词
hemophagocytic lymphohistiocytosis; dengue; dexamethasone; ferritin; HPFH; EPIPODOPHYLLOTOXIN; DIAGNOSIS; FERRITIN;
D O I
10.1097/MPH.0000000000001000
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Hemophagocytic lymphohistiocytosis (HLH) can progress rapidly, often leading to multisystem organ failure and death. Prompt recognition of the syndrome and institution of appropriate treatment are crucial steps in improving the outcome. Dengue virus infection is not commonly known to be associated with secondary HLH. We present a case of a child with dengue fever who subsequently developed classical features of HLH. He was treated successfully with 4 weeks of steroid monotherapy instead of the multidrug therapy proposed in the HLH 2004 protocol. There was prompt response to the treatment with resolution of clinical and biochemical features. He remains in complete remission 3 years from the diagnosis.
引用
收藏
页码:E377 / E379
页数:3
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