Muscling through the microRNA world

被引:110
作者
Callis, Thomas E. [1 ]
Deng, Zhongliang [2 ]
Chen, Jian-Fu [1 ]
Wang, Da-Zhi [1 ]
机构
[1] Univ N Carolina, Carolina Cardiovasc Biol Ctr, Dept Cell & Dev Biol, Chapel Hill, NC 27599 USA
[2] Chongqing Univ Med Sci, Affiliated Hosp 2, Dept Orthopaed Surg, Chongqing 400010, Peoples R China
关键词
cardiac muscle; skeletal muscle; microRNA; gene expression; cardiovascular disease; cell proliferation; cell differentiation;
D O I
10.3181/0709-MR-237
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
microRNAs (miRNAs) are a class of highly conserved small noncoding RNAs that negatively regulate gene expression post-transcriptionally. The emerging field of miRNA biology has begun to unravel roles for these regulatory molecules in a range of biological functions, including cardiac and skeletal muscle development, as well as in muscle-related disease processes. In this paper, we review the role of miRNAs in muscle biology. Recent genetic studies have demonstrated that miRNAs are required for both proper muscle development and function, with crucial roles for miRNAs being identified in regulating muscle cell proliferation and differentiation. Furthermore, dysregulated expression of miRNAs has been correlated to certain muscle-related diseases, including cardiac hypertrophy, cardiac arrhythmias, and muscular dystrophy.
引用
收藏
页码:131 / 138
页数:8
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