Case Report: Acute Transverse Myelitis after Zika Virus Infection

被引：20

作者：

Neri, Vanderson Carvalho ^{[1
]}

Xavier, Maria Filomena ^{[2
]}

Barros, Priscila Oliveira ^{[3
]}

Bento, Cleonice Melo ^{[3
]}

Marignier, Romain ^{[4
,5
,6
]}

Alvarenga, Regina Papais ^{[1
,2
]}

机构：

[1] Univ Fed Estado Rio de Janeiro, Dept Neurol, Rio De Janeiro, Brazil

[2] Hosp Fed Lagoa, Multiple Sclerosis Treatment Ctr, Rio De Janeiro, Brazil

[3] Univ Fed Estado Rio de Janeiro, Dept Microbiol & Parasitol, Rio De Janeiro, Brazil

[4] Hosp Civils Lyon, Hop Neurol PierreWertheimer, OFSEP, Serv Neurol A, Bron, France

[5] Hosp Civils Lyon, Hop Neurol PierreWertheimer, OFSEP, Eugene Devic EDMUS Fdn Multiple Sclerosis, Bron, France

[6] Univ Lyon, Univ Lyon 1, Lyon, France

来源：

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE | 2018年 / 99卷 / 06期

关键词：

GLYCOPROTEIN;

D O I：

10.4269/ajtmh.17-0938

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

We report here one case of Zika virus (ZIKV) infection associated with auto-immunity directed against the central nervous system in a Brazilian woman who developed acute transverse myelitis 9 days after recovery from an acute episode of fever with generalized erythema. Imaging of the spinal cord showed an elongated area on the T1-T10 level with gadolinium uptake. The diagnostic of the ZIKV infection was confirmed by cerebrospinal fluid and serum analysis. This patient had serum positivity for autoantibodies against myelin oligodendrocyte glycoprotein (MOG), a specific antibody against the myelin sheath. We propose that a direct central nervous system infection by ZIKV could lead to a specific auto-immunity against MOG protein.

引用

页码：1419 / 1421

页数：3

共 11 条

[1] Zika virus-associated neurological disorders: a review [J].

Araujo, Abelardo Q. C. ;

Silva, Marcus Tulius T. ;

Araujo, Alexandra P. Q. C. .

BRAIN, 2016, 139 :2122-2130

[2] Zika Virus Outbreak in Rio de Janeiro, Brazil: Clinical Characterization, Epidemiological and Virological Aspects [J].

Brasil, Patricia ;

Calvet, Guilherme Amaral ;

Siqueira, Andre Machado ;

Wakimoto, Mayumi ;

de Sequeira, Patricia Carvalho ;

Nobre, Aline ;

Borges Quintana, Marcel de Souza ;

Lima de Mendonca, Marco Cesar ;

Lupi, Otilia ;

de Souza, Rogerio Valls ;

Romero, Carolina ;

Zogbi, Heruza ;

Bressan, Clarisse da Silveira ;

Alves, Simone Sampaio ;

Lourenco-de-Oliveira, Ricardo ;

Ribeiro Nogueira, Rita Maria ;

Carvalho, Marilia Sa ;

Bispo de Filippis, Ana Maria ;

Jaenisch, Thomas .

PLOS NEGLECTED TROPICAL DISEASES, 2016, 10 (04)

[3] Guillain-Barre Syndrome outbreak associated with Zika virus infection in French Polynesia: a case-control study [J].

Cao-Lormeau, Van-Mai ;

Blake, Alexandre ;

Mons, Sandrine ;

Lastere, Stephane ;

Roche, Claudine ;

Vanhomwegen, Jessica ;

Dub, Timothee ;

Baudouin, Laure ;

Teissier, Anita ;

Larre, Philippe ;

Vial, Anne-Laure ;

Decam, Christophe ;

Choumet, Valerie ;

Halstead, Susan K. ;

Willison, Hugh J. ;

Musset, Lucile ;

Manuguerra, Jean-Claude ;

Despres, Philippe ;

Fournier, Emmanuel ;

Mallet, Henri-Pierre ;

Musso, Didier ;

Fontanet, Arnaud ;

Neil, Jean ;

Ghawche, Frederic .

LANCET, 2016, 387 (10027) :1531-1539

[4] Antibodies to myelin oligodendrocyte glycoprotein in aquaporin 4 antibody seronegative longitudinally extensive transverse myelitis: Clinical and prognostic implications [J].

Cobo-Calvo, Alvaro ;

Sepulveda, Maria ;

Bernard-Valnet, Raphael ;

Ruiz, Anne ;

Brassat, David ;

Martinez-Yelamos, Sergio ;

Saiz, Albert ;

Marignier, Romain .

MULTIPLE SCLEROSIS JOURNAL, 2016, 22 (03) :312-319

[5] Zika Virus in the Americas - Yet Another Arbovirus Threat [J].

Fauci, Anthony S. ;

Morens, David M. .

NEW ENGLAND JOURNAL OF MEDICINE, 2016, 374 (07) :601-604

[6] Current Zika virus epidemiology and recent epidemics [J].

Ioos, S. ;

Mallet, H. -P. ;

Goffart, I. Leparc ;

Gauthier, V. ;

Cardoso, T. ;

Herida, M. .

MEDECINE ET MALADIES INFECTIEUSES, 2014, 44 (07) :302-307

[7] Zika virus and autoimmunity: From microcephaly to Guillain-Barre syndrome, and beyond [J].

Lucchese, Guglielmo ;

Kanduc, Darja .

AUTOIMMUNITY REVIEWS, 2016, 15 (08) :801-808

[8] Acute myelitis due to Zika virus infection [J].

Mecharles, Sylvie ;

Herrmann, Cecile ;

Poullain, Pascale ;

Tran, Tuan-Huy ;

Deschamps, Nathalie ;

Mathon, Gregory ;

Landais, Anne ;

Breurec, Sebastien ;

Lannuzel, Annie .

LANCET, 2016, 387 (10026) :1481-1481

[9] Antibodies to myelin oligodendrocyte glycoprotein in bilateral and recurrent optic neuritis [J].

Ramanathan, Sudarshini ;

Reddel, Stephen W. ;

Henderson, Andrew ;

Parratt, John D. E. ;

Barnett, Michael ;

Gatt, Prudence N. ;

Merheb, Vera ;

Kumaran, Raani-Yogeeta Anusuiya ;

Pathmanandavel, Karrnan ;

Sinmaz, Nese ;

Ghadiri, Mahtab ;

Yiannikas, Con ;

Vucic, Steve ;

Stewart, Graeme ;

Bleasel, Andrew F. ;

Booth, David ;

Fung, Victor S. C. ;

Dale, Russell C. ;

Brilot, Fabienne .

NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION, 2014, 1 (04)

[10] Possible Association Between Zika Virus Infection and Microcephaly - Brazil, 2015 [J].

Schuler-Faccini, Lavinia ;

Ribeiro, Erlane M. ;

Feitosa, Ian M. L. ;

Horovitz, Dafne D. G. ;

Cavalcanti, Denise P. ;

Pessoa, Andre ;

Doriqui, Maria Juliana R. ;

Neri, Joao Ivanildo ;

de Pina Neto, Joao Monteiro ;

Wanderley, Hector Y. C. ;

Cernach, Mirlene ;

El-Husny, Antonette S. ;

Pone, Marcos V. S. ;

Serao, Cassio L. C. ;

Sanseverino, Maria Teresa V. .

MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT, 2016, 65 (03) :59-62

← 1 2 →