MULTIFUNCTIONAL ROLES OF ACTIVINS IN THE BRAIN

被引：25

作者：

Ageta, Hiroshi ^{[1
]}

Tsuchida, Kunihiro ^{[1
]}

机构：

[1] Fujita Hlth Univ, Div Therapies Intractable Dis, Inst Comprehens Med Sci ICMS, Aichi, Japan

来源：

ACTIVINS AND INHIBINS | 2011年 / 85卷

关键词：

GROWTH-FACTOR-BETA; ACTIN-BASED PLASTICITY; EARLY GENE ZIF268; LONG-TERM-MEMORY; PROTEIN-SYNTHESIS; DENDRITIC SPINE; MESSENGER-RNA; ANTIDEPRESSANT TREATMENT; PDZ PROTEIN; I RECEPTOR;

D O I：

10.1016/B978-0-12-385961-7.00009-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Activins, which are members of the TGF-beta superfamily, were initially isolated from gonads and served as modulators of follicle-stimulating hormone secretion. Activins regulate various biological functions, including induction of the dorsal mesoderm, craniofacial development, and differentiation of numerous cell types. Activin receptors are highly expressed in neuronal cells, and activin mRNA expression is upregulated by neuronal activity. Activins also exhibit neuroprotective action during excitotoxic brain injury. However, very little is known about the functional roles of activins in the brain. We recently generated various types of transgenic mice, demonstrating that activins regulate spine formation, behavioral activity, anxiety, adult neurogenesis, late-phase long-term potentiation, and maintenance of long-term memory. The present chapter describes recent progress in the study of the role of activin in the brain. (C) 2011 Elsevier Inc.

引用

页码：185 / 206

页数：22

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