SYNTHESIS AND ANTI-INFLAMMATORY ACTIVITY OF 5-ACYL-1,3,5-DITHIAZINANES

被引：5

作者：

Akhmetova, V. R. ^{[1
]}

Khairullina, R. R. ^{[1
,2
]}

Parfenova, T. I. ^{[1
]}

Sufiyarova, R. Sh. ^{[1
]}

Bashkatov, S. A. ^{[1
]}

Kunakova, R. V. ^{[2
]}

机构：

[1] Russian Acad Sci, Inst Petrochem & Catalysis, Ufa 450075, Bashkortostan, Russia

[2] Ufa State Acad Econ & Serv, Ufa 450077, Bashkortostan, Russia

来源：

PHARMACEUTICAL CHEMISTRY JOURNAL | 2011年 / 44卷 / 10期

关键词：

5-acyl-1,3,5-dithiazinanes; formaldehyde; hydrogen sulfide; carboxylic acid amides; heterocyclization;

D O I：

10.1007/s11094-011-0512-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of 5-acyl-1,3,5-dithiazinanes were synthesized by multicomponent heterocyclization of amides with formaldehyde (CH(2)O) and hydrogen sulfide (H(2)S) in the presence of BuONa. Among the synthesized compounds, 5-trifluoroacetyl-1,3,5-dithiazinane and 5-acetylsalicyloyl-1,3,5-dithiazinane exhibited anti-inflammatory activity comparable with that of aspirin.

引用

页码：534 / 535

页数：2