Preoperative REM Sleep Behavior Disorder and Subthalamic Nucleus Deep Brain Stimulation Outcome in Parkinson Disease 1 Year After Surgery

被引：5

作者：

Besse-Pinot, Elsa ^{[1
]}

Pereira, Bruno ^{[2
]}

Durif, Franck ^{[1
]}

Fantini, Maria Livia ^{[1
]}

Durand, Elodie ^{[1
]}

Debilly, Berengere ^{[1
]}

Derost, Philippe ^{[1
]}

Moreau, Caroline ^{[3
,4
,5
]}

Hainque, Elodie ^{[7
]}

Rouaud, Tiphaine ^{[8
]}

Eusebio, Alexandre ^{[9
,10
]}

Benatru, Isabelle ^{[11
]}

Drapier, Sophie ^{[12
]}

Guehl, Dominique ^{[13
]}

Rascol, Olivier ^{[14
]}

Maltete, David ^{[15
,16
,17
]}

Lagha-Boukbiza, Ouhaid ^{[18
]}

Giordana, Caroline ^{[19
]}

Tir, Melissa ^{[20
]}

Thobois, Stephane ^{[21
]}

Hopes, Lucie ^{[22
]}

Hubsch, Cecile ^{[23
]}

Jarraya, Bechir ^{[24
]}

Rolland, Anne-Sophie ^{[6
]}

Corvol, Jean-Christophe ^{[7
]}

Devos, David ^{[6
]}

Marques, Ana ^{[1
]}

机构：

[1] Univ Clermont Auvergne, Clermont Ferrand Univ Hosp, Neurol Dept, EA7280,NS Pk F CRIN Network, F-63000 Clermont Ferrand, France

[2] Clermont Ferrand Univ Hosp, Biostat Dept, F-63000 Clermont Ferrand, France

[3] CHU Lille, Dept Med Pharmacol, Referent Ctr Parkinsons Dis, INSERM UMRS 1171,Licend, Lille, France

[4] CHU Lille, Dept Neurol, Referent Ctr Parkinsons Dis, INSERM UMRS 1171,Licend, Lille, France

[5] CHU Lille, Dept Movement Disorders, Referent Ctr Parkinsons Dis, INSERM UMRS 1171,Licend, Lille, France

[6] Univ Lille, Dept Med Pharmacol, Lille Neurosci & Cognit, Univ Hosp,INSERM UMR S1172,NS Pk F CRIN Network, Lille, France

[7] Sorbonne Univ, Hop Pitie Salpetriere, AP HP,Inst Cerveau,INSERM CNRS, NS Pk F CRIN Network,Dept Neurol,Paris Brain Inst, Paris, France

[8] Nantes Univ Hosp, NS Pk F CRIN Network, Dept Neurol, Nantes, France

[9] Timone Univ Hosp, AP HM, Dept Neurol, Marseille, France

[10] Inst Neurosci Timone, NS Pk F CRIN Network, Marseille, France

[11] Univ Poitiers, NS Pk F CRIN Network, Dept Neurol, Poitiers, France

[12] Univ Hosp Rennes, NS Pk F CRIN Network, Dept Neurol, Rennes, France

[13] CHU Bordeaux, Ctr Expert Parkinson, Inst Malad Neurodegenerat, NS Pk F CRIN Network, Bordeaux, France

[14] Univ Toulouse 3, Dept Clin Pharmacol & Neurosci, Clin Invest Ctr CIC1436,INSERM,NS Pk F CRIN Netwo, NeuroToul COEN Ctr,Toulouse Univ Hosp,Parkinson E, Toulouse, France

[15] Rouen Univ Hosp, Dept Neurol, Rouen, France

[16] Univ Rouen, Rouen, France

[17] NS Pk F CRIN Network, INSERM U1239, Lab Neuronal & Neuroendocrine Differentiat & Comm, Mont St Aignan, France

[18] Univ Strasbourg, Federat Med Translat Strasbourg FMTS, Strasbourg Univ Hosp, Dept Neurol,NS Pk F CRIN Network, Strasbourg, France

[19] Ctr Hosp Univ Nice, NS Pk F CRIN Network, Dept Neurol, Nice, France

[20] Univ Picardie Jules Verne, EA 4559 Lab Neurosci Fonctionnelles & Pathol, Expert Ctr Parkinsons Dis, Dept Neurol & Neurosurg,Amiens Univ Hosp,NS Pk F, Amiens, France

[21] Univ Claude Bernard Lyon 1, Inst Sci Cognit Marc Jeannerod, Pierre Wertheimer Neurol Hosp,CNRS,UMR 5229 CNRS, Hosp Civils Lyon,Univ Hosp Lyon,Dept Neurol C,NS, Villeurbanne, France

[22] Univ Hosp, Nancy NS, Dept Neurol, NS Pk F CRIN Network, Nancy, France

[23] Hosp Fdn Ophtalmol Adolphe Rothschild, Dept Neurol, NS Pk F CRIN Network, Paris, France

[24] Univ Paris Saclay UVSQ, Hop Foch, Neurosci Pole, INSERM CEA NeuroSpin,NS Pk F CRIN Network, Paris, France

来源：

NEUROLOGY | 2021年 / 97卷 / 20期

关键词：

BILATERAL STIMULATION; SCREENING QUESTIONNAIRE; COGNITIVE IMPAIRMENT; FOLLOW-UP; NEUROSTIMULATION; VALIDATION; SYMPTOMS; APATHY; SCALE;

D O I：

10.1212/WNL.0000000000012862

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background and Objectives To determine whether patients with Parkinson disease (PD) eligible for subthalamic nucleus deep brain stimulation (STN-DBS) with probable REM sleep behavior disorder (RBD) preoperatively could be more at risk of poorer motor, nonmotor, and quality of life outcomes 12 months after surgery compared to those without RBD. Methods We analyzed the preoperative clinical profile of 448 patients with PD from a French multicentric prospective study (PREDISTIM) according to the presence or absence of probable RBD based on the RBD Single Question and RBD Screening Questionnaire. Among the 215 patients with PD with 12 months of follow-up after STN-DBS, we compared motor, cognitive, psycho-behavioral profile, and quality of life outcomes in patients with (pre-opRBD+) or without (pre-opRBD-) probable RBD preoperatively. Results At preoperative evaluation, pre-opRBD+ patients were older (61 +/- 7.2 vs 59.5 +/- 7.7 years; p = 0.02), had less motor impairment (Movement Disorder Society-sponsored version of the Unified Parkinson's Disease Rating Scale [MDS-UPDRS] III "off": 38.7 +/- 16.2 vs 43.4 +/- 7.1; p = 0.03) but more nonmotor symptoms on daily living activities (MDS-UPDRS I: 12.6 +/- 5.5 vs 10.7 +/- 5.3; p < 0.001), had more psychobehavioral manifestations (Ardouin Scale of Behavior in Parkinson's Disease total: 7.7 +/- 5.1 vs 5.1 +/- 0.4; p = 0.003), and had worse quality of life (Parkinson's Disease Questionnaire-39: 33 +/- 12 vs 29 +/- 12; p = 0.03), as compared to pre-opRBD- patients. Both pre-opRBD+ and pre-opRBD- patients had significant MDS-UPDRS IV score decrease (-37% and -33%, respectively), MDS-UPDRS III "med 'off'/stim 'on'" score decrease (-52% and -54%), and dopaminergic treatment decrease (-52% and -49%) after surgery, with no between-group difference. There was no between-group difference for cognitive and global quality of life outcomes. Conclusions In patients with PD eligible for STN-DBS, the presence of probable RBD preoperatively is not associated with a different clinical outcome 1 year after neurosurgery. Classification of Evidence This study provides Class II evidence that in patients with PD eligible for STN-DBS, the presence of probable RBD preoperatively is not associated with poorer outcomes 1 year post surgery.

引用

页码：E1994 / E2006

页数：13

共 48 条

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