A new approach to 19-nor-A-ring phosphine oxide for the convergent synthesis of 19-nor-calcitriol

被引：2
作者：
Sigueiro, Rita [1 ]
Otero, Rocio [1 ]
Gonzalez-Berdullas, Patricia [1 ]
Loureiro, Julian [1 ]
Mourino, Antonio [1 ]
Maestro, Miguel A. [2 ]
机构：
[1] Univ Santiago de Compostela, Dept Quim Organ, Lab Invest Ignacio Ribas, E-15782 Santiago De Compostela, Spain
[2] Univ A Coruna, Dept Quim Fundamental, Fac Ciencias, Campus Zapateira,S-N, E-15071 La Coruna, Spain
来源：
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY | 2017年 / 173卷
关键词：
Vitamin D-3 metabolites; 19-Nor-calcitriol; 19-Nor-A-ring phosphine oxide; Convergent synthesis; VITAMIN-D; SYSTEM; RING;
D O I：
10.1016/j.jsbmb.2016.08.008
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A new approach to 19-nor-A-ring phosphine oxide 5 together with a convergent synthesis of the vitamin D-3 analogue 1 alpha,25-dihydroxy-19-norvitamin D-3 (3) have been developed. The 19-nor-A-ring is constructed from (S)-carvone. The triene system is assembled by a Wittig-Horner coupling. (C) 2016 Elsevier Ltd. All rights reserved.
引用
收藏
页码：86 / 88
页数：3
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