Nickel-Catalyzed Selective Synthesis of α-Alkylated Ketones via Dehydrogenative Cross-Coupling of Primary and Secondary Alcohols

被引：26

作者：

Bains, Amreen K. ^{[1
]}

Biswas, Ayanangshu ^{[1
]}

Adhikari, Debashis ^{[1
]}

机构：

[1] Indian Inst Sci Educ & Res IISER Mohali, Dept Chem Sci, Sas Nagar 140306, Punjab, India

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2022年 / 364卷 / 01期

关键词：

nickel catalysis; cross-coupling; secondary alcohols; radical reaction; METHYLATION; QUINOLINE; METHANOL; CAMPHOR; AMIDES;

D O I：

10.1002/adsc.202101077

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Herein, we describe an isolable, air-stable, homogeneous, nickel catalyst that performs dehydrogenative cross-coupling reaction between secondary and primary alcohols to result alpha-alkylated ketone products selectively. The sequence of steps involve in this one-pot reaction is dehydrogenation of both alcohols, condensation between the ketone and the aldehyde, and hydrogenation of the in situ-generated alpha,beta-unsaturated ketone. Preliminary mechanistic investigation hints a radical mechanism following borrowing hydrogen reaction.

引用

页码：47 / 52

页数：6

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