Nickel-Catalyzed Selective Synthesis of α-Alkylated Ketones via Dehydrogenative Cross-Coupling of Primary and Secondary Alcohols

被引：25
|
作者：
Bains, Amreen K. [1 ]
Biswas, Ayanangshu [1 ]
Adhikari, Debashis [1 ]
机构：
[1] Indian Inst Sci Educ & Res IISER Mohali, Dept Chem Sci, Sas Nagar 140306, Punjab, India
来源：
ADVANCED SYNTHESIS & CATALYSIS | 2022年 / 364卷 / 01期
关键词：
nickel catalysis; cross-coupling; secondary alcohols; radical reaction; METHYLATION; QUINOLINE; METHANOL; CAMPHOR; AMIDES;
D O I：
10.1002/adsc.202101077
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Herein, we describe an isolable, air-stable, homogeneous, nickel catalyst that performs dehydrogenative cross-coupling reaction between secondary and primary alcohols to result alpha-alkylated ketone products selectively. The sequence of steps involve in this one-pot reaction is dehydrogenation of both alcohols, condensation between the ketone and the aldehyde, and hydrogenation of the in situ-generated alpha,beta-unsaturated ketone. Preliminary mechanistic investigation hints a radical mechanism following borrowing hydrogen reaction.
引用
收藏
页码：47 / 52
页数：6
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