The use of hyperpolarized carbon-13 magnetic resonance for molecular imaging

被引:30
作者
Siddiqui, Sarmad [1 ,2 ]
Kadlecek, Stephen [2 ]
Pourfathi, Mehrdad [2 ,3 ]
Xin, Yi [1 ,2 ]
Mannherz, William [1 ]
Hamedani, Hooman [1 ,2 ]
Drachman, Nicholas [2 ]
Ruppert, Kai [2 ]
Clapp, Justin [4 ]
Rizi, Rahim [2 ]
机构
[1] Univ Penn, Dept Bioengn, Philadelphia, PA 19104 USA
[2] Univ Penn, Dept Radiol, Philadelphia, PA 19104 USA
[3] Univ Penn, Dept Elect & Syst Engn, Philadelphia, PA 19104 USA
[4] Hosp Univ Penn, Dept Anesthesiol & Crit Care, 3400 Spruce St, Philadelphia, PA 19104 USA
关键词
Hyperpolarization; DNP; PHIP; MRSI; Pyruvate; Metabolic imaging; Molecular imaging; Cellular imaging; DYNAMIC NUCLEAR-POLARIZATION; PARAHYDROGEN-INDUCED POLARIZATION; POSITRON-EMISSION-TOMOGRAPHY; TO-NOISE RATIO; HYDROGEN-INDUCED POLARIZATION; PYRUVATE-DEHYDROGENASE FLUX; CHEMICAL-SHIFT SEPARATION; RAY-COMPUTED-TOMOGRAPHY; KREBS CYCLE METABOLISM; IN-VIVO MEASUREMENT;
D O I
10.1016/j.addr.2016.08.011
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Until recently, molecular imaging using magnetic resonance (MR) has been limited by the modality's low sensitivity, especially with non-proton nuclei. The advent of hyperpolarized (HP) MR overcomes this limitation by substantially enhancing the signal of certain biologically important probes through a process known as external nuclear polarization, enabling real-time assessment of tissue function and metabolism. The metabolic information obtained by HP MR imaging holds significant promise in the clinic, where it could play a critical role in disease diagnosis and therapeutic monitoring. This review will provide a comprehensive overview of the developments made in the field of hyperpolarized MR, including advancements in polarization techniques and delivery, probe development, pulse sequence optimization, characterization of healthy and diseased tissues, and the steps made towards clinical translation. (C) 2016 Elsevier B.V. All rights reserved.
引用
收藏
页码:3 / 23
页数:21
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