Synthesis of phenylalanine-derived beta-hydroxy and beta-keto phosphine oxides - Investigation of the configurational stability of lithiated phosphine oxides using the Hoffmann test

被引：19
作者：
OBrien, P [1 ]
Warren, S [1 ]
机构：
[1] UNIV CAMBRIDGE,CHEM LAB,CAMBRIDGE CB1 1EW,ENGLAND
来源：
TETRAHEDRON LETTERS | 1996年 / 37卷 / 24期
关键词：
D O I：
10.1016/0040-4039(96)00814-3
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Reaction between a phenylalanine-derived aldehyde and a lithiated phosphine oxide (the Hoffmann test) has been used to demonstrate that lithiated phosphine oxides are not configurationally stable in THF at -78 degrees C on the timescale of thier reaction with the aldehyde. Additionally, these reactions generate synthetically useful products. Copyright (C) 1996 Elsevier Science Ltd
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页码：4271 / 4274
页数：4
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