A Case Series of Facial Depigmentation Associated With Low Fluence Q-Switched 1,064 nm Nd/YAG Laser for Skin Rejuvenation and Melasma

被引:106
作者
Chan, Nicola P. Y. [1 ]
Ho, Stephanie G. Y. [1 ]
Shek, Samantha Y. N. [1 ]
Yeung, Chi K. [1 ]
Chan, Henry H. [1 ,2 ]
机构
[1] Univ Hong Kong, Div Dermatol, Dept Med, Hong Kong, Hong Kong, Peoples R China
[2] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Wellman Ctr Photomed, Boston, MA USA
关键词
laser toning; laser facial; depigmentation; leucoderma punctata; Q-switched 1,064 nm Nd:YAG; laser; non-ablative; skin rejuvenation; melasma; INTENSE PULSED-LIGHT; ND-YAG LASER; REFRACTORY MELASMA; NDYAG LASER; LEUKODERMA PUNCTATA; ALEXANDRITE LASER; PHOTOTHERMOLYSIS; HYPOPIGMENTATION; CO2-LASER; DESIGN;
D O I
10.1002/lsm.20956
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Background and Objective: In recent years, "laser toning" using low fluence, large spot size, multiple passed Q-switched 1,064 nm Nd:YAG laser has gained much popularity in Asian countries for non-ablative skin rejuvenation and the treatment of melasma. This case series highlights one of the complications associated with laser toning, which is facial depigmentation. Materials and Methods: Fourteen patients with laser toning-associated facial depigmentation were assessed with cross-polarized and ultraviolet (UV) photographic images. The laser toning regimens received by these patients, as well as the treatment given for depigmentation, were analyzed retrospectively. Results: All 14 patients were Chinese females, 9 of whom received laser toning for non-ablative skin rejuvenation and the other 5 for melasma. The treatment regimens received by these patients were highly variable. The total number of treatments received ranged from 6 to 50 (mean 22.07). In all cases, UV photographic images demonstrated facial mottled depigmentation. Laser toning failed to significantly improve melasma in all five patients. Five patients received targeted narrowband UVB for depigmentation with good clinical results. Conclusions: Laser toning with low fluence Q-switched 1,064 nm Nd:YAG laser for skin rejuvenation and melasma can be associated with mottled depigmentation. With laser toning being frequently performed, this complication may become more commonly encountered in clinical practice. The depigmentation can appear after only a few treatment sessions, and can cause much disfigurement, especially in cases with background melasma. Further studies on laser toning are needed with the view to optimizing efficacy and minimizing side-effects. Lasers Surg. Med. 42:712- 719, 2010. (C) 2010 Wiley-Liss, Inc.
引用
收藏
页码:712 / 719
页数:8
相关论文
共 34 条
[1]   SELECTIVE PHOTOTHERMOLYSIS OF CUTANEOUS PIGMENTATION BY Q-SWITCHED ND-YAG LASER-PULSES AT 1064, 532, AND 355 NM [J].
ANDERSON, RR ;
MARGOLIS, RJ ;
WATENABE, S ;
FLOTTE, T ;
HRUZA, GJ ;
DOVER, JS .
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1989, 93 (01) :28-32
[2]   Combined ultrapulse CO2 laser and Q-switched alexandrite laser compared with Q-switched alexandrite laser alone for refractory melasma:: Split-face design [J].
Angsuwarangsee, S ;
Polnikorn, N .
DERMATOLOGIC SURGERY, 2003, 29 (01) :59-64
[3]  
[Anonymous], 2008, DERMATOL SURG
[4]   Evaluation of clinical, microscopic, and ultrastructural changes after treatment with a novel Q-switched Nd:YAG laser [J].
Berlin, Alexander L. ;
Dudelzak, Jacob ;
Hussain, Mussarrat ;
Phelps, Robert ;
Goldberg, David J. .
JOURNAL OF COSMETIC AND LASER THERAPY, 2008, 10 (02) :76-79
[5]   Confetti-like hypopigmentation: a rare complication of common phototherapeutic modality [J].
Bhatnagar, A. ;
Kanwar, A. J. ;
Parsad, D. ;
Narang, T. ;
De, D. .
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY, 2007, 21 (09) :1276-1277
[6]   An animal study of the effects on p16 and PCNA expression of repeated treatment with high-energy laser and intense pulsed light exposure [J].
Chan, Henry H. L. ;
Yang, C. H. ;
Leung, Joseph C. K. ;
Wei, W. I. ;
Lai, K. N. .
LASERS IN SURGERY AND MEDICINE, 2007, 39 (01) :8-13
[7]   Melasma treatment in Korean women using a 1064-nm Q-switched Nd:YAG laser with low pulse energy [J].
Cho, S. B. ;
Kim, J. S. ;
Kim, M. J. .
CLINICAL AND EXPERIMENTAL DERMATOLOGY, 2009, 34 (08) :E847-E850
[8]   Leukoderma punctatum following systemic PUVA therapy [J].
Dogra, S ;
Jain, R ;
Parsad, D ;
Handa, S .
INTERNATIONAL JOURNAL OF DERMATOLOGY, 2002, 41 (12) :922-923
[9]   LEUKODERMA PUNCTATA [J].
FALABELLA, R ;
ESCOBAR, CE ;
CARRASCAL, E ;
ARROYAVE, JA .
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 1988, 18 (03) :485-494
[10]   3D in-vivo optical skin imaging for topographical quantitative assessment of non-ablative laser technology [J].
Friedman, PM ;
Skover, GR ;
Payonk, G ;
Kauvar, ANB ;
Geronemus, RG .
DERMATOLOGIC SURGERY, 2002, 28 (03) :199-204