VEGF-receptor signal transduction

被引:515
作者
Cross, MJ
Dixelius, J
Matsumoto, T
Claesson-Welsh, L
机构
[1] Dept Genet & Pathol, S-75185 Uppsala, Sweden
[2] Nihon Univ, Sch Med, Dept Internal Med 2, Itabashi Ku, Tokyo 1738610, Japan
关键词
D O I
10.1016/S0968-0004(03)00193-2
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The vascular endothelial growth factor (VEGF) family of ligands and receptors has been the focus of attention in vascular biology for more than a decade. There is now a consensus that the VEGFs are crucial for vascular development and neovascularization in physiological and pathological processes in both embryo and adult. This has facilitated a rapid transition to their use in clinical applications, for example, administration of VEGF ligands to enhance vascularization of ischaemic tissues and, conversely, inhibitors of VEGF-receptor function in anti-angiogenic therapy. More recent data indicate essential roles for the VEGFs in haematopoietic cell function and in lymphangiogenesis.
引用
收藏
页码:488 / 494
页数:7
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