VEGF-receptor signal transduction

被引：511
作者：
Cross, MJ
Dixelius, J
Matsumoto, T
Claesson-Welsh, L
机构：
[1] Dept Genet & Pathol, S-75185 Uppsala, Sweden
[2] Nihon Univ, Sch Med, Dept Internal Med 2, Itabashi Ku, Tokyo 1738610, Japan
来源：
TRENDS IN BIOCHEMICAL SCIENCES | 2003年 / 28卷 / 09期
关键词：
D O I：
10.1016/S0968-0004(03)00193-2
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The vascular endothelial growth factor (VEGF) family of ligands and receptors has been the focus of attention in vascular biology for more than a decade. There is now a consensus that the VEGFs are crucial for vascular development and neovascularization in physiological and pathological processes in both embryo and adult. This has facilitated a rapid transition to their use in clinical applications, for example, administration of VEGF ligands to enhance vascularization of ischaemic tissues and, conversely, inhibitors of VEGF-receptor function in anti-angiogenic therapy. More recent data indicate essential roles for the VEGFs in haematopoietic cell function and in lymphangiogenesis.
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收藏
页码：488 / 494
页数：7
相关论文
共 80 条
[1]   Molecular mechanisms of lymphangiogenesis in health and disease [J].
Alitalo, K ;
Carmeliet, P .
CANCER CELL, 2002, 1 (03) :219-227
[2]   Migration of human monocytes in response to vascular endothelial growth factor (VEGF) is mediated via the VEGF receptor flt-1 [J].
Barleon, B ;
Sozzani, S ;
Zhou, D ;
Weich, HA ;
Mantovani, A ;
Marme, D .
BLOOD, 1996, 87 (08) :3336-3343
[3]   HERV-K-T47D-related long terminal repeats mediate polyadenylation of cellular transcripts [J].
Baust, C ;
Seifarth, W ;
Germaier, H ;
Hehlmann, R ;
Leib-Mösch, C .
GENOMICS, 2000, 66 (01) :98-103
[4]   VEGF-induced paracellular permeability in cultured endothelial cells involves urokinase and its receptor [J].
Behzadian, MA ;
Windsor, LJ ;
Ghaly, N ;
Liou, G ;
Tsai, NT ;
Caldwell, RB .
FASEB JOURNAL, 2003, 17 (02) :752-+
[5]   Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis [J].
Bergers, G ;
Brekken, R ;
McMahon, G ;
Vu, TH ;
Itoh, T ;
Tamaki, K ;
Tanzawa, K ;
Thorpe, P ;
Itohara, S ;
Werb, Z ;
Hanahan, D .
NATURE CELL BIOLOGY, 2000, 2 (10) :737-744
[6]   Effects of angiogenesis inhibitors on multistage carcinogenesis in mice [J].
Bergers, G ;
Javaherian, K ;
Lo, KM ;
Folkman, J ;
Hanahan, D .
SCIENCE, 1999, 284 (5415) :808-812
[7]   Impaired myocardial angiogenesis and ischemic cardiomyopathy in mice lacking the vascular endothelial growth factor isoforms VEGF164 and VEGF188 [J].
Carmeliet, P ;
Ng, YS ;
Nuyens, D ;
Theilmeier, G ;
Brusselmans, K ;
Cornelissen, I ;
Ehler, E ;
Kakkar, VV ;
Stalmans, I ;
Mattot, V ;
Perriard, JC ;
Dewerchin, M ;
Flameng, W ;
Nagy, A ;
Lupu, F ;
Moons, L ;
Collen, D ;
D'Amore, PA ;
Shima, DT .
NATURE MEDICINE, 1999, 5 (05) :495-502
[8]   Targeted deficiency or cytosolic truncation of the VE-cadherin gene in mice impairs VEGF-mediated endothelial survival and angiogenesis [J].
Carmeliet, P ;
Lampugnani, MG ;
Moons, L ;
Breviario, F ;
Compernolle, V ;
Bono, F ;
Balconi, G ;
Spagnuolo, R ;
Oosthuyse, B ;
Dewerchin, M ;
Zanetti, A ;
Angellilo, A ;
Mattot, V ;
Nuyens, D ;
Lutgens, E ;
Clotman, F ;
de Ruiter, MC ;
Gittenberger-de Groot, A ;
Poelmann, R ;
Lupu, F ;
Herbert, JM ;
Collen, D ;
Dejana, E .
CELL, 1999, 98 (02) :147-157
[9]   A vascular endothelial growth factor antagonist is produced by the human placenta and released into the maternal circulation [J].
Clark, DE ;
Smith, SK ;
He, YL ;
Day, KA ;
Licence, DR ;
Corps, AN ;
Lammoglia, R ;
Charnock-Jones, DS .
BIOLOGY OF REPRODUCTION, 1998, 59 (06) :1540-1548
[10]   The vascular endothelial growth factor receptor Flt-1 mediates biological activities - Implications for a functional role of placenta growth factor in monocyte activation and chemotaxis [J].
Clauss, M ;
Weich, H ;
Breier, G ;
Knies, U ;
Rockl, W ;
Waltenberger, J ;
Risau, W .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (30) :17629-17634
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