(iv) The use of bone morphogenetic proteins (BMPs) in long-bone non-unions

被引：17

作者：

Dinopoulos, Haralampos ^{[1
]}

Giannoudis, Peter V. ^{[1
]}

机构：

[1] Leeds Teaching Hosp NHS Trust, Leeds Gen Infirm, Acad Unit, Dept Trauma & Orthopaed, Leeds LS1 3EX, W Yorkshire, England

来源：

CURRENT ORTHOPAEDICS | 2007年 / 21卷 / 04期

关键词：

bone morphogenetic proteins (BMPs); recombinant (rh); BMP-2 and rh-BMP-7; Osteogenic protein-1; (OP-1); long-bone non-unions;

D O I：

10.1016/j.cuor.2007.07.007

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

The use of bone morphogenetic proteins (BMPs) in treating the clinical challenge posed by fracture delayed and non-union is still under investigation. When used to supplement basic surgical management clinical trials white few in number have demonstrated that BMPs are effective and safe for human application and have an efficacy comparable with that of autologous bone-grafting and eliminate donor site morbidity and reduces the risk of infection at the recipient site. Level one evidence has shown that recombinant human bone morphogenetic protein-7 (rh-BMP-7 or OP-1) is a reasonable alternative to autologous bone grafting in the treatment of long bone non-unions. (C) 2007 Elsevier Ltd. All rights reserved.

引用

页码：268 / 279

页数：12

共 116 条

[1] Economic considerations for the use of recombinant human bone morphogenetic protein-2 in open tibial fractures in Europe: The German model [J].