Mitochondrial dysfunctions, endothelial progenitor cells and diabetic retinopathy

被引：22
作者：
Shao, Yan [1 ,2 ,3 ]
Li, Xiaorong [1 ,2 ]
Wood, John W. [3 ]
Ma, Jian-xing [3 ]
机构：
[1] Tianjin Med Univ, Eye Hosp, Eye Inst, Tianjin, Peoples R China
[2] Tianjin Med Univ, Eye Hosp, Sch Optometry & Ophthalmol, Tianjin, Peoples R China
[3] Univ Oklahoma, Hlth Sci Ctr, Dept Physiol, Oklahoma City, OK 73014 USA
来源：
JOURNAL OF DIABETES AND ITS COMPLICATIONS | 2018年 / 32卷 / 10期
基金：
美国国家卫生研究院;
关键词：
Diabetic retinopathy; Endothelial progenitor cell; Mitochondrial dysfunction; Stem cell fate; EPC therapy; HEMATOPOIETIC STEM-CELLS; OXIDATIVE STRESS; CD34(+) CELLS; GROWTH-FACTOR; PROLIFERATIVE RETINOPATHY; EPIRETINAL MEMBRANES; SIGNALING PATHWAY; DIFFERENTIATION; SENESCENCE; AUTOPHAGY;
D O I：
10.1016/j.jdiacomp.2018.06.015
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Aim: Diabetic retinopathy (DR) is the leading cause of vision loss in the working age population. Endothelial progenitor cells (EPC) play a vital role in vascular damage repair. This article will review recent progress regarding mitochondrial and EPC dysfunction associated with DR. Results: EPCs represent a limited population of adult stem cells possessing vasculogenic potential postnatally; their number and function are changed in DR. Among all the function changes, mitochondrial dysfunction plays an important role in the dysregulation of EPCs, as mitochondria regulate energy balance, and cell fate determination. Conclusions: Although the mechanism for the role of mitochondria dysregulation in EPC function remains elusive, mitochondria of EPCs represent a promising target for the treatment of the vasculopathy presented within DR. (C) 2018 Elsevier Inc. All rights reserved.
引用
收藏
页码：966 / 973
页数：8
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